1-Ethyl-1-nitrosourea

  • Ethylnitrosourea
  • N-Ethylnitrosourea
  • N-Ethyl-N-nitrosourea
  • Nitrosoethylurea
  • Urea, N-ethyl-N-nitroso
  • Urea, 1-ethyl-1-nitroso
Formula
C3H7N3O2
Structure
Description
Yellow-pink crystals or off-white powder.
Uses
Experimentally as mutagen, ethylating agent.

Registry Numbers and Inventories.
CAS
759-73-9
EC (EINECS/ELINCS)
212-072-2
RTECS
YT3150000
RTECS class
Tumorigen; Mutagen; Reproductive Effector
Merck
12,3879
Beilstein/Gmelin
1761174
Beilstein Reference
3-04-00-00233
RCRA
U176
Swiss Giftliste 1
G-5259
Canada DSL/NDSL
NDSL
US TSCA
Listed

Properties.
Formula
C3H7N3O2
Formula mass
117.10
Melting point, °C
103
Boiling point, °C
327
Solubility in water
Soluble
Partition coefficient, pKow
0.23

Hazards and Protection.
Storage
Store at stocks in the dark at less than -10 C in tightly closed containers. Protect from moisture. Store at working quantities and its solutions in a safety refrigerator in the laboratory work area.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
If you spill this chemical, you should dampen the solid spill material with 5% acetic acid, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% acetic acid to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% acetic acid followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Diazoethane, a highly explosive gas is produced upon alkaline hydrolysis. Decomposition products may be explosive. Sealed bottles may explode at room temperature due to gas pressure.
Incompatibilities
Sensitive to moisture and light Incompatible with water and nucleophilic reagents.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Carcinogin
I-2A, N-2, CP65
Poison_Class
1*
Exposure effects
The toxicological properties of this material have not been investigated.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
USCG CHRIS Code
NEU