1'-Hydroxysafrole

  • 1,3-Benzodioxole-5-(2-propen-1-ol)
  • 1,2-Methylenedioxy-4-(1-hydroxyallyl)benzene
Formula
C10H10O3
Structure

Registry Numbers and Inventories.
CAS
5208-87-7
RTECS
DF4920000
RTECS class
Tumorigen; Mutagen; Natural Product
Beilstein/Gmelin
167676
Beilstein Reference
4-19-00-00802

Properties.
Formula
C10H10O3
Formula mass
178.20
Boiling point, °C
121 - 123 (3 torr)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Rapid heart rate, abnormally low blood pressure, and respiratory paralysis have occurred after the ingestion of sassafras oil. stupor, vertigo, and aphasia have been reported following ingestion. Hallucinations and trembling of the arms and hands have been seen. Spermatogenesis in mice was affected following intraperitoneal administration of safrole (Lewis, 1991).
   Ingestion
Abdominal pain and vomiting may be seen.
   Inhalation
Tightness in the chest and respiratory paralysis may occur.
   Skin
Diaphoresis and flushing of the skin has been reported in an adult who drank up to 10 cups of sassafras tea. Sassafras oil is a mild dermal irritant.
   Eyes
Sassafras is a mild mucous membrane irritant. Dilated pupils may be seen. Sassafras is loss of a mucous membrane irritant then other volatile oils.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Exposed eyes should be irrigated with copious amounts of room temperature water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, an ophthalmologic examination should be performed.

Transport.