1-Phenyl-2-thiourea

  • Phenylthiocarbamide
  • Phenylthiourea
  • N-Phenylthiourea
  • 1-Phenylthiourea
  • U 6324
Formula
C6H5NHCSNH2
Structure
Description
Needle-like crystals.
Uses
In medical genetics.

Registry Numbers and Inventories.
CAS
103-85-5
EC (EINECS/ELINCS)
203-151-2
R 26/28 43
S 22 28 36/37 45
RTECS
YU1400000
RTECS class
Tumorigen; Mutagen; Reproductive Effector
UN (DOT)
2811
Merck
12,7468
Beilstein/Gmelin
907309
Beilstein Reference
4-12-00-00804
RCRA
P093
Swiss Giftliste 1
G-6968
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C7H8N2S
Formula mass
152.22
Melting point, °C
84 - 85
Boiling point, °C
295-297
Vapor pressure, mmHg
0.009 (25 C)
Density
1.33 g/cm3
Solubility in water
Soluble
pKa/pKb
13.12 (pKa)
Partition coefficient, pKow
0.73
Heat of vaporization
50.5 kJ/mol

Hazards and Protection.
Storage
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked.
Handling
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Use spark-proof tools and explosion proof equipment. Avoid contact with skin and eyes. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Discard contaminated shoes.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal shipping and handling conditions.
Incompatibilities
Strong acids, strong bases, acids, acid fumes, strong oxidizing agents
Decomposition
Nitrogen oxides, sulfur dioxide, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
115
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Water or foam may cause frothing. In case of fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Dangerous disaster hazard; emits toxic fumes of oxides of sulfur and nitrogen when heated to decomposition. Avoid acids or acid fumes.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
4
 
Flammability
0
 
 
Reactivity
0
 

Health.
Poison_Class
1
Exposure effects
May cause bone marrow abnormalities with damage to blood forming tissues.
   Ingestion
May be fatal if swallowed. May cause irritation of the digestive tract. Poison by ingestion.
   Inhalation
May cause respiratory tract irritation.
   Skin
Causes skin irritation.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. SPEED IS ESSENTIAL. A DOCTOR MUST BE NOTIFIED AT ONCE. Induce vomiting only when instructed to do so by a physician.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
USCG CHRIS Code
PTU