12-Crown-4

  • 12-Crown-4-ether
  • Ethylene oxide cyclic tetramer
  • 1,4,7,10-Tetraoxacyclododecane
Formula
C8H16O4
Structure
Description
Clear, colorless liquid.

Registry Numbers and Inventories.
CAS
294-93-9
EC (EINECS/ELINCS)
206-036-5
RTECS
XF0550000
RTECS class
Drug; Reproductive Effector; Primary Irritant
Beilstein/Gmelin
1363064
Beilstein Reference
5-19-11-00334
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C8H16O4
Formula mass
176.21
Melting point, °C
16
Boiling point, °C
254
Vapor pressure, mmHg
0.03 (25 C)
Density
1.10296 g/cm3 (25 C)
Solubility in water
Soluble
Refractive index
1.4607 (25 C)
Partition coefficient, pKow
-0.54
Heat of vaporization
47.2 kJ/mol
Heat of combustion
-4738 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Wash thoroughly after handling. Wash hands before eating. Use with adequate ventilation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment.
Disposal code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents and strong acids.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
120
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Health.
Exposure effects
Prolonged or repeated exposure may cause adverse reproductive effects.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
HS Code
2932 99 95