12-o-Tetradecanoylphorbol 13-acetate

  • 13-o-Acetylphorbol 12-myristate
  • (Hydroxymethyl)-1,1,6,8-beta-tetramethyl-9a-acetate 9-myristate
  • Factor a1
  • Factor a1
  • Tetrahydroxy-3-(Hydroxymethyl)-1,1,6,8-alpha-Tetramethyl-5H-Cyclopropa(3,4)benz
  • Pentahydroxy-tigliadienone-monoacetate(C)monomyristate(B)
Formula
C36H56O8
Structure
Description
White crystals.
Uses
In cancer research to study mechanisms of tumor promotion, to screen for potential inhibiting agents, and as positive control for tumor promoting agents.

Registry Numbers and Inventories.
CAS
16561-29-8
RTECS
QH4377000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Primary Irritant
Beilstein/Gmelin
2407201
New Zealand
Listed

Properties.
Formula
C36H56O8
Formula mass
616.84
Melting point, °C
72.2

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container. Deep freeze (below -20 C).
Handling
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
No data.
Incompatibilities
Strong oxidizing agents, strong bases.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
This material is probably combustible.

Health.
Exposure effects
   Ingestion
Poison by ingestion.
   Inhalation
Toxic if inhaled.
   Skin
Toxic in contact with skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid immediately. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.