1,2,3,4-Tetrahydro-9-aminoacridine

  • 9-Amino-1,2,3,4-tetrahydroacridine
  • 1,2,3,4-Tetrahydro-9-acridinamine
  • THA
  • CS-12602
  • Tacrine
Formula
C13H14N2
Structure
Description
White solid.
Uses
pharmaceutical

Registry Numbers and Inventories.
CAS
321-64-2
EC (EINECS/ELINCS)
206-291-2
RTECS
AR9532100
RTECS class
Tumorigen; Drug; Mutagen; Human Data
UN (DOT)
2811
Merck
12,9199
Beilstein/Gmelin
147610
Beilstein Reference
5-22-10-00480

Properties.
Formula
C13H14N2
Formula mass
198.27
Melting point, °C
183 - 184
Boiling point, °C
358
Solubility in water
Soluble
pKa/pKb
4.36 (pKb)
Partition coefficient, pKow
2.91

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, acid chlorides, acid anhydrides.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
   Ingestion
Harmful if swallowed.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III