1,3-Dichloro-4-nitrobenzene

  • 2,4-Dichloro-1-nitrobenzene
Formula
1,3-(Cl)2C6H3-4-(NO2)
Structure
Description
Light yellow needles or amber crystalline solid.
Uses
Chemical intermediate for diazoxide (an antihypertensive agent).

Registry Numbers and Inventories.
CAS
611-06-3
EC (EINECS/ELINCS)
210-248-3
EC Class
harmful, sensitizing, dangerous for the environment
R 23/24/25 33 36/38
S 28 36/37/39 45
RTECS
CZ5420000
RTECS class
Mutagen
UN (DOT)
1578
Beilstein/Gmelin
1451655
Beilstein Reference
4-05-00-00726
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H3Cl2NO2
Formula mass
192.00
Melting point, °C
28 - 31
Boiling point, °C
258
Vapor pressure, mmHg
0.75 (45 C)
Vapor density (air=1)
6.6
Density
1.4434 g/cm3 (75 C)
Solubility in water
188 g/L
Surface tension
41.3 g/s2 (35 C)
Refractive index
1.5512 (78.1 C)
Partition coefficient, pKow
3.07

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Disposal code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
152
Autoignition, °C
500
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This chemical is combustible.
Hazards
Containers may explode when heated.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
Rapid heart rate, rapid breathing, abnormally low blood pressure, and respiratory depression may occur. Headache, dizziness, lethargy, and coma are possible. Nitrobenzene is a possible animal teratogen.
   Ingestion
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
1578
Response guide
Hazard class
6.1
Packing Group
II
 
HS Code
2904 90 85