2-Aminopyridine

  • 2-Pyridinamine
  • alpha-Aminopyridine
  • o-Aminopyridine
  • 2-Pyridylamine
Formula
2-(NH2)C5H4N
Structure
Description
Colorless crystalline solid, characteristic, unpleasant odor, white leaflets or large colorless crystals, white powder or crystals.
Uses
Intermediate in chemical synthesis.

Registry Numbers and Inventories.
CAS
504-29-0
EC (EINECS/ELINCS)
207-988-4
EC Class
toxic, irritant
R 21 23/25 33 36/37/38
S 26 36/37/39 45
RTECS
US1575000
RTECS class
Human Data
UN (DOT)
2671
Merck
13,472
Beilstein/Gmelin
105785
Beilstein Reference
5-22-08-00280
Swiss Giftliste 1
G-1093
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C5H6N2
Formula mass
94.12
Melting point, °C
50 - 52
Boiling point, °C
210.6
Vapor pressure, mmHg
0.2 (25 C)
Vapor density (air=1)
3.25
Saturation Concentration
1053 ppm (0.10%) (calculated)
Density
1.24 g/cm3
Solubility in water
Highly soluble
Refractive index
1.56552 (65 C)
pKa/pKb
7.20 (pKb)
Partition coefficient, pKow
0.48
Heat of fusion
15.30 kJ/mol
Heat of vaporization
52.75 kJ/mol
Heat of combustion
-2856 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Disposal code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents, strong acids, acid chlorides, acid anhydrides
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
93
Autoignition, °C
> 630
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Containers may explode in the heat of a fire. Combustible solid. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
This chemical is combustible.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Toxic gases and vapors (such as oxides of nitrogen and carbon monoxide) may be released in a fire involving 2-aminopyridine.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure limit(s)
TLV: 0.5 ppm; 1.9 mg/m3 (as TWA) (ACGIH 1993-1994). OSHA PEL: TWA 0.5 ppm (2 mg/m3) NIOSH REL: TWA 0.5 ppm (2 mg/m3) NIOSH IDLH: 5 ppm
Poison_Class
2
Exposure effects
Weakness, dizziness, disorientation, hyperexcitibility, tremors, periorbital paresthesias and tonic-clonic seizures may be noted.
   Ingestion
May be fatal if swallowed. May cause irritation of the digestive tract. Poison by ingestion. May cause effects similar to those for inhalation exposure. An oral dose of 590 mg/kg of 4-aminopyridine in a man produced shortness of breath, nausea, vomiting, hallucinations and distorted perception. Affects the CNS to produce tremor, excitability and convulsions.
   Inhalation
Causes respiratory tract irritation. May cause severe headaches, nausea, increased blood pressure, weakness, convulsions, and a stuporous state.
   Skin
Causes skin irritation. May be fatal if absorbed through the skin. Substance is rapidly absorbed through the skin. Causes symptoms similar to those of inhalation. Causes redness and pain.
   Eyes
Causes eye irritation. Causes redness and pain.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2671
Response guide
Hazard class
6.1
Packing Group
II
 
7. Aliphatic amines
HS Code
2933 39 99