2-Chloro-1-nitrobenzene

  • o-Chloronitrobenzene
  • o-Nitrochlorobenzene
  • 1-Chloro-2-nitrobenzene
Formula
C6H4ClNO2
Structure
Description
Yellow to green crystals with a characteristic odor.
Uses
Chemical intermediate for carbofuran, a pesticide, other ints, eg, o-nitrophenol, 2-chloroaniline, dyes (former use).

Registry Numbers and Inventories.
CAS
88-73-3
EC (EINECS/ELINCS)
201-854-9
EC Class
toxic, dangerous for the environment
R 23/24/25 33
S 28 37 45
RTECS
CZ0875000
RTECS class
Tumorigen; Mutagen; Reproductive Effector
UN (DOT)
1578
Merck
13,2170
Beilstein/Gmelin
509273
Beilstein Reference
50-00-00721
Swiss Giftliste 1
G-5456
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C6H4ClNO2
Formula mass
157.56
Melting point, °C
33
Boiling point, °C
246
Vapor pressure, mmHg
0.07 (25 C)
Vapor density (air=1)
5.44
Saturation Concentration
52.64 ppm (0.0052%) at 25 C (calculated)
Critical temperature
484
Critical pressure
39.3
Density
1.368 g/cm3 (20 C)
Solubility in water
0.34 g/L (20 C)
Viscosity
2.09 cp (25 C)
Surface tension
45 g/s2 (40 C)
Refractive index
1.56747 (35 C)
Dipole moment
4.33 D
Dielectric constant
17.8 (33 C)
Partition coefficient, pKow
2.24
Heat of vaporization
65.9 kJ/mol
Heat of combustion
-2925 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Disposal code
2
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, ammonia. Reacts violently with reducing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
97
Autoignition, °C
470
Upper exp. limit, %
8.8
Lower exp. limit, %
1.4
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.
Fire potential
Slightly flammable. Combustion requires preheating. Moderate hazard.
Hazards
Containers may explode when heated.
Combustion products
Ignites at high temperatures with evolution of nitrogen oxide and chloride fumes.
Health
3
 
Flammability
1
 
 
Reactivity
0
 

Health.
Poison_Class
2
Exposure effects
May cause liver and kidney damage. May cause anemia and other blood cell abnormalities. May cause fatigue, dizziness, headache, insomnia and weight loss.
   Ingestion
Harmful if swallowed. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. May cause central nervous system depression. May cause cyanosis, characterized by bluish skin, Headache, nausea and shortness of breath.
   Inhalation
May cause effects similar to those described for ingestion.
   Skin
Causes skin irritation. Harmful if absorbed through the skin. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May be absorbed through skin.
   Eyes
Causes eye irritation, redness and pain.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1578
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
CNO
 
42 Nitrocompounds
HS Code
2904 90 85
 
IMO Pollution Category
B
IMO Hazard code
S/P