2-Chloro-4-nitroaniline

  • 2-Chloro-4-nitrobenzenamine
  • 1-amino-2-chloro-4-nitrobenzene
Formula
C6H5ClN2O2
Structure
Description
Yellow crystalline powder.
Uses
Intermediate in manufacture of dyes.

Registry Numbers and Inventories.
CAS
121-87-9
EC (EINECS/ELINCS)
204-502-2
EC Index Number
610-009-00-7
EC Class
Harmful; Dangerous for the Environment
R 22 51/53
S 22 24 61
RTECS
BX1400000
RTECS class
Mutagen
UN (DOT)
2237
Beilstein/Gmelin
638657
Beilstein Reference
4-12-00-01675
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H5ClN2O2
Formula mass
172.58
Melting point, °C
105
Boiling point, °C
326
Vapor pressure, mmHg
0.0002 (25 C)
Vapor density (air=1)
5.9
Density
1 g/cm3 (20 C)
Solubility in water
0.23 g/L
Partition coefficient, pKow
2.14
Heat of vaporization
56.8 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Take precautionary measures against static discharges. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Oxidizing agents, strong acids, strong bases.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
151
Autoignition, °C
522
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Containers may explode when heated. Runoff from fire control or dilution water may cause pollution. Extinguishing media: For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
Combustible material: may burn but does not ignite readily.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
2 ppm TWA ACGIH
Exposure effects
May cause liver and kidney damage. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death. Effects may be delayed. May cause cyanosis - a blue-gray coloring of the skin and lips caused by a lack of oxygen.
   Ingestion
May cause irritation of the digestive tract. May cause liver and kidney damage. May cause cardiac disturbances. May cause methemoglobinemia, cyanosis, convulsions, and death. May cause headache. May cause nausea and vomiting. May cause central nervous system depression.
   Inhalation
May cause respiratory tract irritation. May cause methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea, and death. May cause liver and kidney damage. May cause cardiac abnormalities. Inhalation at high concentrations may cause CNS depression and asphixiation.
   Skin
Absorption into the body may cause cyanosis. Causes redness and pain.
   Eyes
May cause eye irritation. Causes redness and pain.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2237
Response guide
Hazard class
6.1
Packing Group
III