2-Chloro-N,N-dimethylaniline

  • o-Chloro-N,N-dimethylaniline
Formula
C8H10ClN
Structure

Registry Numbers and Inventories.
CAS
698-01-1
Beilstein/Gmelin
2205740
Beilstein Reference
4-12-00-01116

Properties.
Formula
C8H10ClN
Formula mass
155.62
Boiling point, °C
206 - 208
Vapor pressure, mmHg
0.23 (25 C)
Density
1.1067 g/cm3 (20 C)
Solubility in water
Insoluble
Refractive index
1.5472 (20 C)
pKa/pKb
9.60 (pKb)
Heat of vaporization
44.4 kJ/mol

Hazards and Protection.

Fire.
Flash Point,°C
74

Health.
Exposure effects
   Ingestion
Nausea and vomiting may occur. Metabolic acidosis may develop secondary to tissue hypoxia.
   Inhalation
Dyspnea and tachypnea may occur. CNS effects include headache, dizziness, altered mental status, confusion, lethargy progressing to coma seizures and syncope; these occur secondary to CNS hypoxia, usually with levels > 20 percent.
   Skin
Central cyanosis unresponsive to oxygen therapy is classic.
   Eyes
Causes severe irritation.

First aid
 
   Ingestion
Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old Consider gastroc ;avage after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Protect airway by placement in Trendelenburg and left lateral decubitus position or by endotracheal intubation. Control any seizures first.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, for respiratory tract irritation bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids.
   Skin
Skin should be thoroughly washed with soap and water. Contaminated clothing and shoes should be discarded Seek medical attention. Administer 100 percent humidified supplemental oxygen with assisted ventilation as required. Treat for methemoglobinemia and sequelae. Signs and symptoms of methemoglobinemia may be delayed.
   Eyes
Irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.