2-Methylaniline hydrochloride

  • 1-Amino-2-methylbenzene hydrochloride
  • 2-Amino-1-methylbenzene hydrochloride
  • ortho-Aminotoluene hydrochloride
  • 2-Aminotoluene hydrochloride
  • 1-Methyl-2-aminobenzene hydrochloride
  • 2-Methyl-1-aminobenzene hydrochloride
Formula
2-(CH3)C6H4NH2.HCl
Structure
Description
Green crystals or white crystalline solid.
Uses
Intermediate in manufacture of dyes.

Registry Numbers and Inventories.
CAS
636-21-5
EC (EINECS/ELINCS)
211-252-8
EC Class
carcinogenic, toxic, irritant, dangerous for the environment
R 45 E23/24/25 36 50
S 53 36/37 45 61
RTECS
XU7350000
RTECS class
Tumorigen; Mutagen
UN (DOT)
2811
Beilstein/Gmelin
741981
Beilstein Reference
4-12-00-01744
RCRA
U222
Canada DSL/NDSL
NDSL
US TSCA
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C7H10ClN
Formula mass
143.62
Melting point, °C
218 - 220
Density
1.288 g/cm3 (20 C)
Solubility in water
Very soluble

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Dispensers of liquid detergent should be available. In the laboratory, gloves and protective clothing should always be worn but should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, and disposable plastic aprons might provide additional protection. Protective clothing should be of distinctive color, as a reminder not to be worn outside the laboratory.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Disposal code
9
Stability
No data.
Incompatibilities
Incompatible with oxidizing agents and with alkalis.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Exposure limit(s)
OSHA: PEL (8 h TWA): 5 ppm
Carcinogin
N-2, CP65
Exposure effects
Acute poisoning may cause rapid heart rate and rapid breathing. Severe headache, CNS disturbances, and tremor may occur. A high incidence of gynecological disorders and excess frequency of spontaneous abortions have been noted. The fetal liver can n-oxygenate aniline to form phenylhydroxylamine. Fetal effects include higher levels of methemoglobin those found in than the mother. Fetal poisoning may occur. <br>No data were available to assess the potential effects of exposure to aniline during lactation. <br>No information about possible male reproductive effects was found in available references at the time of this review
   Ingestion
Nausea and vomiting can occur.
   Inhalation
Signs of hypoxia may be present.
   Skin
Dermal absorption is rapid. Cyanosis, moderate skin irritation and sensitization, and dermatitis have been noted.
   Eyes
Cyanosis may occur. Corneal damage, discoloration, and mild to severe irritation of the eyes have been noted.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
2811
Response guide
USCG CHRIS Code
TOH
 
HS Code
2921 43 00