(2-Methylphenyl)thiourea

  • o-Tolylthiourea
  • N-(o-Tolyl)thiourea
Formula
C8H10N2S
Structure
Description
Crystalline solid.

Registry Numbers and Inventories.
CAS
614-78-8
EC (EINECS/ELINCS)
210-395-3
S 22 36/37 45
RTECS
YU2975000
RTECS class
Agricultural Chemical and Pesticide
UN (DOT)
2811
Beilstein/Gmelin
2086802
Beilstein Reference
4-12-00-01766
Canada DSL/NDSL
NDSL
US TSCA
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C8H10N2S
Formula mass
166.24
Melting point, °C
160
Boiling point, °C
295
Solubility in water
Slightly soluble
pKa/pKb
13.14 pKa
Partition coefficient, pKow
1.96

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
(Non-Specific -- Poisonous Solid, n.o.s.) Keep unnecessary people away, isolate hazard area and deny entry. Stay upwind and keep out of low areas. Do not touch spilled material, stop leak if you can do so without risk. Absorb small spills with sand or other noncombustible material and place into containers for later disposal. For large spills, dike far ahead of spill for later disposal.
Stability
No data.
Incompatibilities
Incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents Reactions with these materials generate heat and in many cases hydrogen gas.

Fire.
Fire fighting
(Non-Specific -- Poisonous Solid, n.o.s.) Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing.(Non-Specific -- Poisonous Solid, n.o.s.) For small fires use dry chemical, carbon dioxide, water spray, or foam. Use water spray, fog, or foam on larger fires. Move container from fire area if you can do so without risk.
Hazards
When heated to decomposition, it emits very toxic fumes of oxides of nitrogen and sulfur.

Health.
Exposure effects
   Ingestion
See inhalation.
   Inhalation
The material is highly toxic if orally ingested.
   Skin
Thiourea compounds frequently cause allergic contact dermatitis.
   Eyes
See inhalation

First aid
 
   Ingestion
Do not induce emesis. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists. Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.
UN number
2811
Response guide
USCG CHRIS Code
MTU