2-Nitroaniline

  • o-Nitroaniline
  • 1-Amino-2-nitrobenzene
Formula
C6H6N2O2
Structure
Description
Orange solid with a musty odor.
Uses
Chemical intermediate for ci pigment yellow 5, orange 2, yellow 7, vat red 15, vat orange 7, ci pigment orange 43, vat red 14, disperse yellow 10.

Registry Numbers and Inventories.
CAS
88-74-4
EC (EINECS/ELINCS)
201-855-4
EC Index Number
612-012-00-9
EC Class
Toxic; Danger of cumulative effects; Dangerous for the Environment
R 23/24/25 33 52/53
S 28 36/37 45 61
RTECS
BY6650000
RTECS class
Mutagen
UN (DOT)
1661
Merck
12,6680
Beilstein/Gmelin
509275
Beilstein Reference
4-12-00-01563
RCRA
K101
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H6N2O2
Formula mass
138.13
Melting point, °C
68 - 71
Boiling point, °C
284
Vapor pressure, mmHg
0.003 (25 C)
Density
1.446 g/cm3 (20 C)
Solubility in water
1.1 g/L
Surface tension
40.4 g/s2 (131 C)
Refractive index
1.5362 (100 C)
Partition coefficient, pKow
1.83
Heat of fusion
16.1 kJ/mol
Heat of vaporization
52.4 kJ/mol
Heat of combustion
-3029 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Disposal code
9
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Acids - acid chlorides - acid anhydrides - chloroformates - strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
126
Autoignition, °C
521
Upper exp. limit, %
9.8
Lower exp. limit, %
1.5
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. May polymerize explosively when involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Combustible material; may burn but does not ignite readily. Extinguishing media: Cool containers with flooding quantities of water until well after fire is out. In case of fire, use water spray, dry chemical, carbon dioxide, or alcohol-resistant foam.
Fire potential
Slightly flammable. Flammable at elevated temperatures - moderate hazard.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Toxic oxides of nitrogen may form in fire.
Health
1
 
Reactivity
0
 

Health.
Exposure limit(s)
NIOSH: Potential Occupational Carcinogen.
Exposure effects
Acute poisoning may cause rapid heart rate and rapid breathing. Severe headache, CNS disturbances, and tremor may occur. A high incidence of gynecological disorders and excess frequency of spontaneous abortions have been noted. The fetal liver can n-oxygenate aniline to form phenylhydroxylamine. Fetal effects include higher levels of methemoglobin those found in than the mother. Fetal poisoning may occur. <br>No data were available to assess the potential effects of exposure to aniline during lactation. <br>No information about possible male reproductive effects was found in available references at the time of this review
   Ingestion
May be harmful if swallowed. Causes digestive tract irritation.
   Inhalation
Dust is irritating to the respiratory tract.
   Skin
Causes skin irritation.
   Eyes
Dust may cause mechanical irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1661
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
NTA
 
HS Code
2921 42 10