2-Sulfapyridine

  • 4-[(2-Pyridylamino)sulfonyl]aniline
  • 4-Amino-N-2-pyridinylbenzenesulfonamide
  • 2-Sulfanilamidopyridine
  • N1-2-Pyridylsulfanilamide
  • Haptocil
  • Streptosilpyridine
Formula
C11H11N3O2S
Structure
Description
Odorless or almost odorless white or yellowish-white crystalline powder. Very slightly bitter taste. Aqueous solution is neutral.

Registry Numbers and Inventories.
CAS
144-83-2
EC (EINECS/ELINCS)
205-642-7
RTECS
DA9625000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector
Merck
12,9108
Beilstein/Gmelin
222065
Beilstein Reference
5-22-08-00424
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C11H11N3O2S
Formula mass
249.29
Melting point, °C
188 - 191
Boiling point, °C
474
Vapor pressure, mmHg
4E-9 (25 C)
pKa/pKb
8.54 (pKa)
Partition coefficient, pKow
0.03
Heat of fusion
40.5 kJ/mol
Heat of vaporization
73.7 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
No data.

Fire.
Flash Point,°C
240
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Exposure effects
   Ingestion
See inhalation.
   Inhalation
Symptoms of exposure to this compound include fever, rash, agranulocytosis, deposition of crystals in the urinary tract with consequent hematuria or anuria, nausea, vomiting, cyanosis, sensitization and, rarely, granulocytopenia. Other symptoms include acute transient myopia, conjunctivitis, keratitis, disturbances of the optic nerve and retina, temporary impairment of depth perception, swelling of the eyelids, photophobia, lacrimation, Stevens-Johnson syndrome, Lyell syndrome, amblyopia, central scotoma and optic neuritis, usually with papilledema. It can induce crystalluria.
   Skin
See inhalation.
   Eyes
See inhalation

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.

Transport.