2,3-Epoxypropionaldehyde

  • Epihydrinaldehyde
  • Epihydrine aldehyde
  • 2,3-Epoxypropanal
  • 2,3-Epoxy-1-propanal
  • 2,3-Epoxypropionaldehyde
Formula
C3H4O2
Structure
Description
A colorless liquid.
Uses
As a crosslinking agent for the finishing of wool, for the tanning and fat liquoring of leather, surgical sutures.

Registry Numbers and Inventories.
CAS
765-34-4
EC (EINECS/ELINCS)
212-143-8
RTECS
MB3150000
RTECS class
Tumorigen; Mutagen; Human Data; Primary Irritant
UN (DOT)
2622
Beilstein/Gmelin
103970
Beilstein Reference
5-17-09-00006
RCRA
U126
Swiss Giftliste 1
G-42660

Properties.
Formula
C3H4O2
Formula mass
72.07
Melting point, °C
-62
Boiling point, °C
112
Vapor pressure, mmHg
22 (25 C)
Vapor density (air=1)
2.58
Density
1.07 g/cm3 (20 C)
Solubility in water
Miscible
Refractive index
1.42 (20 C)
Partition coefficient, pKow
-0.73
Heat of vaporization
35.1 kJ/mol

Hazards and Protection.
Storage
Storage location should be close to laboratory where it is to be used, so that only small amounts need to be transported. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should be appropriately labeled. An inventory should be kept showing the quantity of carcinogen and date it was acquired. Facilities for dispensing should be contiguous to storage area.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate clothing to prevent any reasonable probability of skin contact. Wear eye protection to prevent any possibility of eye contact.
Respirators
Self-contained breathing apparatus.
Small spills/leaks
Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.
Stability
Container may explode in heat of fire. Runoff to sewer may create fire or explosion hazards.
Incompatibilities
Flammable and/or toxic gases are generated by the combination with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents Can react with air to give first peroxo acids, and ultimately carboxylic acids React with acids, bases, and oxidizing and reducing agents.

Fire.
Flash Point,°C
31
Fire fighting
Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources.
Fire potential
HIGHLY FLAMMABLE.
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. May polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Combustion products
Fire will produce irritating, corrosive and/or toxic gases.

Health.
Carcinogin
I-2B, CP65
Poison_Class
2
Exposure effects
Shock may develop with severe exposures. Rapid breathing may develop in patients with metabolic acidosis. Reduction in body temperature may be seen. Lethargy and coma may occur following large ingestions or marked inhalation exposure. Formaldehyde has not been shown definitely to be teratogenic in animals. Formaldehyde probably presents little or no risk as a potential human teratogen.
   Ingestion
Nausea, vomiting, and severe abdominal pain may occur following ingestion. Corrosive gastritis, hematemesis, and edema and ulceration of the esophagus may occur. Strictures and perforation are possible delayed complications.
   Inhalation
Inhalation of formaldehyde vapors at elevated concentrations may result in upper respiratory tract irritation and coughing. Severe exposure may result in serious lower respiratory effects, such as bronchitis, pulmonary edema, or pneumonia. Reactive airways may develop in susceptible individuals.
   Skin
Allergic dermatitis and rash may occur.
   Eyes
IRRITATION of the eyes, nose, and throat may occur following exposure to formaldehyde OR fumes from urea-formaldehyde foam and adhesive resins. Corneal opacification and loss of vision may occur following direct eye splash exposure to solutions containing high concentrations of formaldehyde. Transient discomfort and irritation may result from eye exposure to solutions containing low concentrations of formaldehyde.

First aid
 
   Ingestion
Ipecac induced vomiting is not recommended because of the potential for cardiovascular instability. Dilution: following ingestion and/or prior to gastric evacuation, immediately dilute with 4 to 8 ounces (120 to 240 ml) of milk or water (not to exceed 15 ml/kg in a child).
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.
   Eyes
Medical facility: irrigate with sterile 0.9% Saline for at least an hour or until the cul-de-sacs are free of particulate matter and returned to neutrality (confirm with ph paper).

Transport.
UN number
2622
Response guide
Hazard class
3
Packing Group
II
 
USCG CHRIS Code
GCD
 
Std. Transport #
4912448