2,3,5,6-Tetrachloropyridine is a commercially important derivative that is utilized in the manufacture of pesticides.
Registry Numbers and Inventories.
R 20/21/22 36/37/38
S 26 36/37/39
Japan ENCS (MITI)
Melting point, °C
88 - 89
Boiling point, °C
Vapor pressure, mmHg
0.03 (25 C)
Solubility in water
13.3 mg/L (25 C)
Partition coefficient, pKow
Heat of vaporization
Hazards and Protection.
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Depending on the extent of possible contact, workers should be provided with personal protective equipment. Rubber and plastic gloves should not be relied upon to prevent skin contact because pyridine and many of its derivatives penetrate these materials.
A charcoal gas mask canister respirator has been found to be effective against a 2% pyridine concentration at 30 L/min for 1 hr.
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Strong oxidizing agents.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
No data were available to assess the potential effects of exposure to this agent during pregnancy or lactation. <br>Animal studies on chick for substituted pyridines have shown teratogenicity. Injected chicken eggs develop leg and skeletal malformations.
Irritation may result in abdominal pain with vomiting, or diarrhea.
Severe acute intoxications may result in respiratory depression and death.
Skin irritation may result from repeated or prolonged exposure or photosensitivity.
The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.