2,3,7,8-Tetrachlorodibenzofuran

  • Dibenzofuran, 2,3,7,8-tetrachloro
  • TCDBF
  • TCDF
Formula
C12H4Cl4O
Structure
Uses
There is no industrial use for pcdfs.

Registry Numbers and Inventories.
CAS
51207-31-9
RTECS
HP5295200
RTECS class
Tumorigen; Mutagen; Reproductive Effector
Beilstein/Gmelin
1430934
Beilstein Reference
5-17-02-00238

Properties.
Formula
C12H4Cl4O
Formula mass
305.96
Melting point, °C
227 - 228
Boiling point, °C
392
Solubility in water
6.9E-4 mg/L (26 C)
Partition coefficient, pKow
4.93

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure limit(s)
IDHL: NIOSH considers chlorodiphenyl containing 54% chlorine to be potential occupational carcinogens.
Exposure effects
Peripheral neuropathy, with sensory impairment and lower extremity weakness, central neuropathy, mental status changes, headache and dizziness occur after exposure. Mild exposure may result in asymptomatic EMG alterations. Dioxins have not been proven to produce adverse reproductive effects in humans. However, low birthweights, ectodermal dysplasia, and growth and neurological deficits have been associated with dioxin exposure. Data on spontaneous abortions, decreased sperm quality and feminizing alterations of sex hormones have been mixed. TCDD accumulates in breast milk, and neurolgical deficits and increases in T4 and TSH have been associated with lactational exposure. TCDD is considered an animal teratogen.
   Ingestion
Right-upper-quadrant pain, anorexia, nausea and vomiting may be early symptoms. Pancreatitis occurred in one case of industrial exposure.
   Inhalation
Dyspnea may be noted.
   Skin
The initial dermal reaction is extensive inflammation of exposed areas with photosensitivity, followed by development of chloracne.

First aid
 
   Ingestion
Administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
Move victim to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, pneumonitis or bronchits. Administer oxygen and assist ventilation as required.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. Seek medical attention if irritation or pain persists. Personnel involved in washing patients should wear gloves and avoid contact with contaminated clothing.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, tearing, or sensitivity to light persist, the patient should be seen in a health care facility.

Transport.