- Dibenzofuran, 2,3,7,8-tetrachloro
There is no industrial use for pcdfs.
Registry Numbers and Inventories.
Tumorigen; Mutagen; Reproductive Effector
Melting point, °C
227 - 228
Boiling point, °C
Solubility in water
6.9E-4 mg/L (26 C)
Partition coefficient, pKow
Hazards and Protection.
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Strong oxidizing agents.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
IDHL: NIOSH considers chlorodiphenyl containing 54% chlorine to be potential occupational carcinogens.
Peripheral neuropathy, with sensory impairment and lower extremity weakness, central neuropathy, mental status changes, headache and dizziness occur after exposure. Mild exposure may result in asymptomatic EMG alterations. Dioxins have not been proven to produce adverse reproductive effects in humans. However, low birthweights, ectodermal dysplasia, and growth and neurological deficits have been associated with dioxin exposure. Data on spontaneous abortions, decreased sperm quality and feminizing alterations of sex hormones have been mixed. TCDD accumulates in breast milk, and neurolgical deficits and increases in T4 and TSH have been associated with lactational exposure. TCDD is considered an animal teratogen.
Right-upper-quadrant pain, anorexia, nausea and vomiting may be early symptoms. Pancreatitis occurred in one case of industrial exposure.
Dyspnea may be noted.
The initial dermal reaction is extensive inflammation of exposed areas with photosensitivity, followed by development of chloracne.
Administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
Move victim to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, pneumonitis or bronchits. Administer oxygen and assist ventilation as required.
Remove contaminated clothing and wash exposed area thoroughly with soap and water. Seek medical attention if irritation or pain persists. Personnel involved in washing patients should wear gloves and avoid contact with contaminated clothing.
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, tearing, or sensitivity to light persist, the patient should be seen in a health care facility.