2,4,6-Collidine

  • 2,4,6-Trimethylpyridine
  • sym-Collidine
Formula
(CH3)3C5H2N
Structure
Description
Colorless liquid. Aromatic odor.
Uses
Chemical intermediate.

Registry Numbers and Inventories.
CAS
108-75-8
EC (EINECS/ELINCS)
203-613-3
EC Class
flammable, harmful, irritant
R 10 21/22 36/37/38
S 26 36/37/39
RTECS
UU0970000
RTECS class
Other
UN (DOT)
1992
Merck
12,9848
Beilstein/Gmelin
107283
Beilstein Reference
5-20-06-00093
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C8H11N
Formula mass
121.18
Melting point, °C
-43
Boiling point, °C
171
Vapor pressure, mmHg
34 (80 C)
Vapor density (air=1)
4.2
Critical temperature
380
Density
0.9191 g/cm3 (20 C)
Solubility in water
Slightly soluble
Viscosity
1.11 cp (15 C)
Surface tension
34.75 g/s2 (0 C)
Refractive index
1.4953 (16.4 C)
Dielectric constant
6.6 (20 C)
pKa/pKb
6.57 (pKb)
Partition coefficient, pKow
1.88
Heat of fusion
9.5 kJ/mol
Heat of vaporization
50.33 kJ/mol
Heat of combustion
-4689 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Use spark-proof tools and explosion proof equipment. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not get on skin or in eyes. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition. Provide ventilation.
Disposal code
5
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
55
Upper exp. limit, %
8.9
Lower exp. limit, %
1
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers.
Fire potential
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers.
Combustion products
Fire will produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure effects
Overexposure may cause delayed kidney injury. Chronic ingestion may cause liver damage. Prolonged or repeated eye contact may cause conjunctivitis. Chronic ingestion may cause neurological symptoms.
   Ingestion
Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. May cause central nervous system effects and/or neurological effects.
   Inhalation
May cause liver and kidney damage. May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema.
   Skin
Causes skin irritation. Prolonged and/or repeated contact may cause irritation and/or dermatitis.
   Eyes
Causes eye irritation. May cause conjunctivitis.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
1992
Response guide
Hazard class
3
Packing Group
I; II; III
 
HS Code
2933 39 99