2,4,6-Trimethylphenol

  • Benzene, 2-hydroxy-1,3,5-trimethyl
  • 2-Hydroxymesitylene
  • 1-Hydroxy-2,4,6-trimethylbenzene
  • Mesitol
  • Mesityl alcohol
  • Phenol, 2,4,6-trimethyl
Formula
C9H12O
Structure
Description
White to beige, crystalline powder.
Uses
Chemical intermediate for poly(2,6-dimethyl-1,4-phenylene oxide) & its phosphate ester.

Registry Numbers and Inventories.
CAS
527-60-6
EC (EINECS/ELINCS)
208-419-2
S 26 36/37/39 45
RTECS
OX6590000
RTECS class
Other
UN (DOT)
1759
Beilstein/Gmelin
1859675
Beilstein Reference
4-06-00-03253
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C9H12O
Formula mass
136.21
Melting point, °C
74
Boiling point, °C
56 (0.1 torr)
Vapor pressure, mmHg
0.05
Density
1.046 g/cm3 (20 C)
Solubility in water
1.01 g/L at 25 C
pKa/pKb
10.88 (pKa)
Partition coefficient, pKow
2.73

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container. Corrosives area.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Organic canister mask; face shield; rubber gloves; other protective clothing to prevent contact with skin. In fire conditions, wear goggles and self contained breathing apparatus. Wear appropriate chemical protective gloves, boots and goggles.
Respirators
Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Wear appropriate protective clothing and gloves to prevent skin exposure.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
No data.
Incompatibilities
Bases, acid chlorides, oxidizing agents, copper, copper alloys, brass, steel, acid anhydrides.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. In case of fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
Abnormally low blood pressure, reduced body temperature, rapid breathing, and rapid heart rate may develop with severe toxicity. Initial CNS excitation, including seizures, is commonly followed by CNS depression ranging from lethargy to coma and death. Fetotoxicity and skeletal abnormalities have been reported in animal experiments.
   Ingestion
Phenol is extremely corrosive and may cause oral and esophageal burns and abdominal pain following ingestion.
   Inhalation
Tachypnea is commonly reported; pulmonary edema and bronchospasm may also occur. Stridor has been reported from exposure to high concentrations of phenol. Respiratory arrest occurred 30 minutes post ingestion of 26.7 Grams of phenol in one case.
   Skin
Phenol is corrosive to the skin, but because of anesthetic qualities, it will numb rather than causing a burning pain on contact. Skin becomes red and swollen, then white and opaque. Deep burns result that may become gangrenous.
   Eyes
Causes burns.

First aid
 
   Ingestion
Dilution - may enhance absorption of phenol, and should be avoided. Ipecac induced vomiting is not recommended because of the potential for cns depression and seizures. Activated charcoal - may limit systemic toxicity if administered soon after ingestion, but may interfere with endoscopic evaluation of gastrointestinal burns.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Remove phenol with undiluted polyethylene glycol 300 to 400 or isopropyl alcohol prior to washing, if readily available. Wash exposed areas twice with large quantities of water. A physician may need to examine the exposed area if irritation or pain persist after the area is washed.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.
UN number
1759
Response guide
Hazard class
8
Packing Group
I; II; III
 
21. Phenols. Cresols