3-Amino-1-propanol

  • 3-Aminopropanol
  • 3-Aminopropan-1-ol
  • beta-Alaninol
  • 3-Hydroxy-1-aminopropane
  • 3-Hydroxy-1-propylamine
  • gamma-Aminopropanol
Formula
C3H9NO
Structure
Description
Clear colorless to pale yellow liquid with a fishy odor.
Uses
Chemical intermediate for dexpanthenol, a gastrointestinal drug.

Registry Numbers and Inventories.
CAS
156-87-6
EC (EINECS/ELINCS)
205-864-4
EC Class
harmful, corrosive
R 21 34
S 23 26 36
RTECS
UA5600000
RTECS class
Reproductive Effector; Primary Irritant
UN (DOT)
2735
Beilstein/Gmelin
4231142
Swiss Giftliste 1
G-1788
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C3H9NO
Formula mass
75.11
Melting point, °C
11
Boiling point, °C
187
Vapor pressure, mmHg
0.18 (25 C)
Vapor density (air=1)
2.59
Critical temperature
325
Critical pressure
53.7
Density
0.982 g/cm3 (20 C)
Solubility in water
Miscible
Surface tension
44.7 g/s2 (25 C)
Refractive index
1.46 (20 C)
Dipole moment
2.67 D
pKa/pKb
4.09 (pKa)
Partition coefficient, pKow
-1.12
Heat of vaporization
49.5 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Disposal code
1
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
79
Autoignition, °C
375
Upper exp. limit, %
10.6
Lower exp. limit, %
2.5
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Combustible Liquid. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers.
Fire potential
Combustible liquid and vapor.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Toxic oxides of nitrogen may form in fire.
Health
3
 
Flammability
2
 
 
Reactivity
0
 

Health.
Poison_Class
4
Exposure effects
Effects may be delayed.
   Ingestion
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May cause systemic effects.
   Inhalation
Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May cause systemic effects. Inhalation at high concentrations may cause CNS depression and asphixiation.
   Skin
Causes skin burns. May be harmful if absorbed through the skin. May cause irritation and dermatitis. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
   Eyes
Causes eye burns. May cause chemical conjunctivitis and corneal damage.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
   Eyes
Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Transport.
UN number
2735
Response guide
Hazard class
8
Packing Group
I; II; III
 
USCG CHRIS Code
PLA
 
HS Code
2922 19 80
 
IMO Chemical Code
17
IMO Pollution Category
C
IMO Hazard code
S/P