3-Aminophenol

  • m-Aminophenol
  • 3-Amino-1-hydroxybenzene
  • 3-Hydroxyanaline
Formula
3-(NH2)C6H4OH
Structure
Description
White crystals or off-white flakes.
Uses
3-Aminophenol has been used as a stabilizer of chlorine-containing thermoplastics, although its principal use is as an intermediate in the production of 4-amino-2-hydroxybenzoic acid this isomer is also employed as a hair colorant and as a coupler molecule in hair dyes.

Registry Numbers and Inventories.
CAS
591-27-5
EC (EINECS/ELINCS)
209-711-2
EC Index Number
612-127-00-4
EC Class
Harmful; Dangerous for the Environment
R 20/22 51/53
RTECS
SJ4900000
RTECS class
Mutagen; Reproductive Effector; Primary Irritant
UN (DOT)
2512
Merck
13,459
Beilstein/Gmelin
636059
Beilstein Reference
4-13-00-00952
Swiss Giftliste 1
G-6906
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H7NO
Formula mass
109.13
Melting point, °C
122
Boiling point, °C
299
Vapor pressure, mmHg
0.0007 (25 C)
Density
1.275 g/cm3
Solubility in water
35 g/L
pKa/pKb
9.70 (pKb)
Partition coefficient, pKow
0.34
Heat of vaporization
56.0 kJ/mol
Heat of combustion
-3167 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal.
Disposal code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Acids, acid chlorides, acid anhydrides, chloroformates, strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
92
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
This material is probably combustible.
Hazards
Containers may explode when heated.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure limit(s)
OEL-RUSSIA:STEL 1 mg/m3
Poison_Class
4
Exposure effects
May cause reproductive and fetal effects.
   Ingestion
May cause irritation of the digestive tract. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
Causes skin irritation.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2512
Response guide
Hazard class
6.1
Packing Group
III
 
HS Code
2922 29 00