3-Chloro-4-methylphenyl isocyanate

  • 3-Chloro-p-tolyl isocyanate
  • 2-Chloro-4-isocyanato-1-methylbenzene
Formula
C8H6ClNO
Structure
Description
Colorless to yellowish liquid with an irritating odor, probable lachrymator.
Uses
Used to make other chemicals.

Registry Numbers and Inventories.
CAS
28479-22-3
EC (EINECS/ELINCS)
249-050-7
EC Class
very toxic, corrosive, sensitizing, dangerous for the environment
R 26 36/37/38 42
S 23 26 28 36/37/39 45
UN (DOT)
2236
Beilstein/Gmelin
2690771
Canada DSL/NDSL
NDSL
US TSCA
Listed

Properties.
Formula
C8H6ClNO
Formula mass
167.5
Melting point, °C
23.5
Boiling point, °C
225
Vapor pressure, mmHg
1.5 (20 C)
Saturation Concentration
Approximately 11,850 ppm (1.2%) at 50 C (calculated)
Density
1.224 g/cm3 (20 C)
Solubility in water
Decomposes, Insoluble
Refractive index
1.56 (20 C)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
D1A
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Apply water spray or mist to knock down vapors. Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. Water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses.
Stability
No data.
Incompatibilities
Incompatible with many classes of compounds, reacting exothermically to release toxic gases Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat.

Fire.
Flash Point,°C
110
Autoignition, °C
635
Fire fighting
Use water in flooding quantities as fog. Use alcohol foam, dry chemical or carbon dioxide. Apply water from as far a distance as possible. Keep run-off water out of sewers and water sources.
Fire potential
May burn but does not ignite readily.
Hazards
Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Combustion products
Fire will produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
   Ingestion
See Inhalation.
   Inhalation
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns, or death.
   Skin
See Inhalation.
   Eyes
See Inhalation.

First aid
 
   Ingestion
Seek medical assistance.
   Inhalation
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.
   Skin
Remove and isolate contaminated clothing and shoes. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
   Eyes
Immediately flush with running water for at least 20 minutes.

Transport.
UN number
2236
Response guide
Hazard class
6.1
Packing Group
II
 
HS Code
2929 10 90
 
Std. Transport #
4921740