3-Chloroaniline

  • m-Chloroaniline
  • 3-Chlorobenzamine
  • 1-Amino-3-chlorobenzene
  • Orange GC base
Formula
C6H6ClN
Structure
Description
Colorless to light amber liquid, characteristic sweet odor.
Uses
Chemical intermediate for the herbicide chlorpropham, m-chlorophenyl isocyanurate, pharmaceuticals, & azo dyes & pigments.

Registry Numbers and Inventories.
CAS
108-42-9
EC (EINECS/ELINCS)
203-581-0
EC Index Number
612-010-00-8
EC Class
toxic, dangerous for the environment
R 23/24/25 33 50/53
S 28 36/37 45 60 61
RTECS
BX0350000
RTECS class
Tumorigen; Mutagen
UN (DOT)
2019
Merck
13,2136
Beilstein/Gmelin
605969
Beilstein Reference
4-12-00-01137
Swiss Giftliste 1
G-4900
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H6ClN
Formula mass
127.57
Melting point, °C
-10.4
Boiling point, °C
230.5
Vapor pressure, mmHg
8.7 (100 C)
Vapor density (air=1)
1.206
Saturation Concentration
Less than 130 ppm at 30 C (calculated)
Critical temperature
460
Critical pressure
46.4
Density
1.216 g/cm3 (20 C)
Solubility in water
Insoluble
Viscosity
3.50 cp (25 C)
Surface tension
45.68 g/s2 (20 C)
Refractive index
1.5941 (20 C)
pKa/pKb
10.48 (pKb)
Partition coefficient, pKow
1.88
Heat of vaporization
60.9 kJ/mol
Heat of combustion
-770 kJ/mol

Hazards and Protection.
Storage
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Provide ventilation.
Disposal code
9
Stability
Stable under normal temperatures and pressures. Substance may undergo color change upon exposure to light and air.
Incompatibilities
Acids, acid chlorides, acid anhydrides, strong oxidizing agents, chloroformates.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
124
Autoignition, °C
705
Upper exp. limit, %
8.8
Lower exp. limit, %
1.5
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam. Do NOT use straight streams of water.
Fire potential
This chemical is combustible.
Hazards
Containers may explode when heated.
Combustion products
Irritating and toxic hydrogen chloride and oxides of nitrogen may form in fires.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Poison_Class
3
Exposure effects
May cause cancer according to animal studies.
   Ingestion
Harmful if swallowed. May cause irritation of the digestive tract. May cause liver and kidney damage. May cause methemoglobinemia, cyanosis, convulsions, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May cause central nervous system effects. May cause discoloration of the lips, tongue, and mucous membranes.
   Inhalation
Harmful if inhaled. May cause respiratory tract irritation. May cause effects similar to those described for ingestion.
   Skin
Causes skin burns. Substance is rapidly absorbed through the skin. If absorbed, may cause symptoms similar to those for ingestion.
   Eyes
Causes eye burns.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Induce vomiting by giving one teaspoon of Syrup of Ipecac. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2019
Response guide
Hazard class
6.1
Packing Group
II
 
HS Code
2921 42 10