3-Hydroxy-3-methylglutaric acid

  • 3-Hydroxy-3-methylpentanedioic acid
  • Dicrotalic acid
  • Medroglutaric acid
  • Lipoglutaren
  • beta-Hydroxy-beta-methylglutaric acid
Formula
C6H10O5
Structure
Uses
An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids.

Registry Numbers and Inventories.
CAS
503-49-1
EC (EINECS/ELINCS)
207-971-1
22 24/25
RTECS
MA3753000
RTECS class
Drug
Merck
12,5852
Beilstein/Gmelin
1769194
Beilstein Reference
4-03-00-01166

Properties.
Formula
C6H10O5
Formula mass
162.14
Melting point, °C
110
Boiling point, °C
354
Solubility in water
Very soluble
pKa/pKb
3.95 (pKa)
Heat of vaporization
69.4 kJ/mol

Hazards and Protection.
Storage
Keep container closed. Store in a cool dry place. Store at -20 C
Protection
Rubber gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Incompatibilities
Bases, Oxidizing agents, Reducing agents.
Decomposition
Carbon monoxide, Carbon dioxide.

Fire.
Flash Point,°C
182
Fire fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Water spray. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Health.
Exposure effects
Avoid contact and inhalation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
Contamination of the eyes should be treated by immediate and prolonged irrigation with copious amounts of water.

Transport.