3-Hydroxypropionitrile

  • Ethylene cyanohydrin
  • Hydracrylonitrile
Formula
HOCH2CH2CN
Structure
Description
Clear, colorless to very slightly yellow liquid with a weak odor.
Uses
Solvent for certain cellulose esters and inorganic salts, organic intermediate for acrylates.

Registry Numbers and Inventories.
CAS
109-78-4
EC (EINECS/ELINCS)
203-704-8
R 36/37/38
RTECS
MU5250000
RTECS class
Primary Irritant
Merck
13,3828
Beilstein/Gmelin
635773
Beilstein Reference
4-03-00-00708
RCRA
D003
Swiss Giftliste 1
G-4152
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C3H5NO
Formula mass
71.08
Melting point, °C
-46
Boiling point, °C
228
Decomposition point, °C
>228
Vapor pressure, mmHg
0.08 (25 C)
Vapor density (air=1)
2.45
Critical temperature
429
Density
1.0588 g/cm3 (0 C)
Solubility in water
Miscible
Viscosity
35.71 g/(cm s) (25 C)
Refractive index
1.4272 (20 C)
Dipole moment
3.84 D
Partition coefficient, pKow
-0.94

Hazards and Protection.
Storage
Store in a cool, dry place. Keep away from water. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Keep from contact with moist air and steam.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not get water on spilled substances or inside containers.
Disposal code
6
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Acids, bases, strong oxidizing agents, moisture.
Decomposition
Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
128
Autoignition, °C
494
Upper exp. limit, %
12.1
Lower exp. limit, %
2.3
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Extinguishing media: Water or foam may cause frothing. Do NOT get water inside containers. For large fires, use water spray, fog or alcohol-resistant foam. Cool containers with flooding quantities of water until well after fire is out. For small fires, use dry chemical or carbon dioxide.
Fire potential
Flammable, combustion requires preheating quite flammable.
Hazards
Closed containers may rupture violently when heated. Water Reactive. Material will react with water and may release a flammable and/or toxic gas.
Combustion products
Toxic gases are generated when heated.
Health
1
 
Flammability
1
 
 
Reactivity
2
 
 
Special
W

Health.
Poison_Class
4
Exposure effects
Repeated exposure may cause kidney damage and digestive tract abnormalities.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
USCG CHRIS Code
ETC
 
20 Alcohols, Glycols
HS Code
2926 90 95
 
IMO Chemical Code
17
IMO Pollution Category
D
IMO Hazard code
S