3-Methylpyridine

  • 3-Picoline
  • m-Picoline
Formula
C6H7N
Structure
Description
Colorless liquid with an unpleasant odor.
Uses
Solvent, intermediate in dye and resins industries, in manufacture of insecticides, waterproofing agents, niacin and niacinamide.

Registry Numbers and Inventories.
CAS
108-99-6
EC (EINECS/ELINCS)
203-636-9
EC Class
flammable, harmful, irritant
R 10 20/21/22 36/37/38
S 26 36/37/39
RTECS
TJ5000000
RTECS class
Tumorigen; Primary Irritant
UN (DOT)
2313
Merck
12,7555
Beilstein/Gmelin
1366
Beilstein Reference
5-20-05-00506
Swiss Giftliste 1
G-3180
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C6H7N
Formula mass
93.13
Melting point, °C
-19.4
Boiling point, °C
141 - 143
Vapor pressure, mmHg
4.5 (20 C)
Vapor density (air=1)
3.21
Critical temperature
372
Critical pressure
46.2
Density
0.957 g/cm3 (20 C)
Solubility in water
Soluble
Viscosity
0.972 cp (25 C)
Surface tension
36.7 g/s2 (25 C)
Refractive index
1.5043 (20 C)
Dielectric constant
10.7 (22 C)
pKa/pKb
8.32 (pKb)
Partition coefficient, pKow
1.29
Heat of fusion
12.6 kJ/mol
Heat of vaporization
37.4 kJ/mol
Heat of combustion
-3432 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Remove all sources of ignition.
Disposal code
5
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents, hydrogen peroxide, iron (III) sulfate, sulfuric acid
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
36
Autoignition, °C
537
Upper exp. limit, %
8.7
Lower exp. limit, %
1.3
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Extinguishing media: Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water. For large fires, use water spray, fog or regular foam. For small fires, use dry chemical, carbon dioxide, water spray or regular foam.
Fire potential
This chemical is flammable.
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.
Combustion products
Fire will produce irritating, corrosive and/or toxic gases.
Health
3
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
PDK (as mixture of isomers): 5 mg/m3 (USSR 1991).
Poison_Class
3
Exposure effects
No data were available to assess the potential effects of exposure to this agent during pregnancy or lactation. <br>Animal studies on chick for substituted pyridines have shown teratogenicity. Injected chicken eggs develop leg and skeletal malformations.
   Ingestion
May cause irritation of the digestive tract. Intoxication may include weight loss, diarrhea, weakness, ataxia, and unconsciousness.
   Inhalation
Causes irritation of mucous membrane. Vapors may cause dizziness or suffocation. Exposure may give rise to flushing of face, skin rash, an increase in heart and respiration rates, headaches, giddiness, nausea, and vomiting.
   Skin
Causes skin irritation.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2313
Response guide
Hazard class
3
Packing Group
III
 
USCG CHRIS Code
MLP
 
9 Aromatic amines
HS Code
2933 39 99
 
IMO Chemical Code
17
IMO Pollution Category
C
IMO Hazard code
S/P