3-Pyridinecarbonitrile

  • 3-Cyanopyridine
  • Nicotinonitrile
  • 3-Pyridylcarbonitrile
  • Nicotinic acid nitrile
  • 3-Pyridyl cyanide
  • 3-Azabenzonitrile
Formula
3-(CN)C5H4N
Structure
Description
Needles from petroleum ether.
Uses
Org synthesis.

Registry Numbers and Inventories.
CAS
100-54-9
EC (EINECS/ELINCS)
202-863-0
EC Class
harmful, irritant
S 22 36/37
RTECS
QT3030000
RTECS class
Other
UN (DOT)
2811
Beilstein/Gmelin
65995
Beilstein Reference
4-17-00-01442
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H4N2
Formula mass
104.11
Melting point, °C
48 - 51
Boiling point, °C
206.2
Vapor pressure, mmHg
0.3
Density
1.1590 g/cm3 (25 C)
Solubility in water
140 g/L
pKa/pKb
12.61 (pKb)
Partition coefficient, pKow
0.36
Heat of vaporization
43.9 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Use with adequate ventilation. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Provide ventilation.
Disposal code
6
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
88
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
1
 

Health.
Exposure effects
No data were available to assess the potential effects of exposure to this agent during pregnancy or lactation. <br>Animal studies on chick for substituted pyridines have shown teratogenicity. Injected chicken eggs develop leg and skeletal malformations.
   Ingestion
Causes gastrointestinal tract irritation. Effects may be delayed. May be harmful if swallowed.
   Inhalation
Effects may be delayed. Causes respiratory tract irritation.
   Skin
Causes severe skin irritation. Effects may be delayed.
   Eyes
Causes severe eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
HS Code
2933 39 99