3,5-Diiodosalicylic acid

  • 3,5-Diiodo-2-hydroxybenzoic acid
  • 2-Hydroxy-3,5-diiodobenzoic acid
  • 2-Hydroxy-3,5-diiodobenzenecarboxylic acid
Formula
C7H4I2O3
Structure
Description
White to cream powder.
Uses
Used as an iodine source in foods.

Registry Numbers and Inventories.
CAS
133-91-5
EC (EINECS/ELINCS)
205-124-0
EC Class
irritant
R 22 36/37/38
S 26 36/37/39
RTECS
VO2800000
RTECS class
Agricultural Chemical and Pesticide; Drug
UN (DOT)
2811
Merck
13,3212
Beilstein/Gmelin
2615358
Beilstein Reference
4-10-00-00226
Canada DSL/NDSL
NDSL
US TSCA
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C7H4I2O3
Formula mass
389.91
Boiling point, °C
381
Vapor pressure, mmHg
2E-6 (25 C)
Solubility in water
Insoluble
pKa/pKb
2.07 (pKa)
Partition coefficient, pKow
4.56
Heat of vaporization
66.4 kJ/mol
Heat of combustion
-2930 kJ/mol

Hazards and Protection.
Storage
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents - strong bases.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen iodide.

Fire.
Flash Point,°C
184
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Chronic ingestion of iodides during pregnancy has resulted in fetal death, severe goiter and cretinoid appearance of the newborn..
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed. Chronic ingestion of iodides during pregnancy has resulted in fetal death, severe goiter, and cretinoid appearance of the newborn.
   Inhalation
May cause respiratory tract irritation.
   Skin
Causes skin irritation.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or symptoms occur.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2811
Response guide
HS Code
2918 29 90