3,5-Xylenol

  • 3,5-Dimethylphenol
  • 1-Hydroxy-3,5-dimethylbenzene
Formula
3,5-(CH3)2C6H3OH
Structure
Description
Colorless to off-white crystalline solid.
Uses
Chemical intermediate for p-chloro- and 2,4-dichloro-m-xylenol-biocides.

Registry Numbers and Inventories.
CAS
108-68-9
EC (EINECS/ELINCS)
203-606-5
EC Index Number
604-037-00-9
EC Class
Toxic; Corrosive
R 24/25 34
S 26 28 36/37/39 45
RTECS
ZE6475000
RTECS class
Tumorigen; Reproductive Effector; Primary Irritant
UN (DOT)
2261
Merck
12,10215
Beilstein/Gmelin
774117
Beilstein Reference
4-06-00-03141
Swiss Giftliste 1
G-3802
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C8H10O
Formula mass
122.17
Melting point, °C
61 - 64
Boiling point, °C
222
Vapor pressure, mmHg
0.07 (25 C)
Odor Threshold Odor threshold 4.10 X 10-5 mg/m3
Critical temperature
493
Critical pressure
53.2
Density
0.9680 g/cm3 (20 C)
Solubility in water
4.8 g/L
Viscosity
2.42 cp at 80C
Surface tension
28.42 g/s2 (74 C)
Refractive index
1.5362 (20 C)
pKa/pKb
10.18 (pKa)
Partition coefficient, pKow
2.35
Heat of fusion
17.4 kJ/mol
Heat of vaporization
47.7 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions.
Disposal code
9
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Bases - acid chlorides - acid anhydrides - oxidizing agents - corrodes steel - brass - copper - copper alloys.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
82
Autoignition, °C
> 500
Upper exp. limit, %
6.4
Lower exp. limit, %
1.1
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
This material is probably combustible.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Poison_Class
4
Exposure effects
Chronic ingestion may cause effects similar to those of acute ingestion.
   Ingestion
May cause irritation of the digestive tract. May be harmful if swallowed. A case of fatal xylenol ingestion by a long stay mental hospital patient is described. Clinical course was similar to that observed in other phenolic poisonings with active bowel sounds, nausea, vomiting, severe metabolic acidosis, hypotension, and cardiac and renal failure.
   Inhalation
May cause respiratory tract irritation.
   Skin
Causes skin irritation. May cause skin burns.
   Eyes
Causes eye irritation. May cause eye burns.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2261
Response guide
Hazard class
6.1
Packing Group
II
 
20. Alcohols. Glycols
HS Code
2907 14 00