4-Aminodiphenyl

  • 4-Aminobiphenyl
  • Biphenylamine
  • (1,1'-Biphenyl)-4-amine
  • p-Xenylamine
  • Biphenyl-4-ylamine
Formula
C12H11N
Structure
Description
Colorless to yellowish-brown crystals or light brown solid.
Uses
In detection of sulfates, formerly as rubber antioxidant. As carcinogen in cancer research.

Registry Numbers and Inventories.
CAS
92-67-1
EC (EINECS/ELINCS)
202-177-1
EC Index Number
612-072-00-6
EC Class
Carcinogenic Category 1; Harmful
RTECS
DU8925000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Mutagen
UN (DOT)
3259
Merck
12,1276
Beilstein/Gmelin
386533
Beilstein Reference
4-12-00-03241
Swiss Giftliste 1
G-4325
Canada DSL/NDSL
NDSL
US TSCA
Listed
New Zealand
Listed

Properties.
Formula
C12H11N
Formula mass
169.23
Melting point, °C
55
Boiling point, °C
302
Vapor pressure, mmHg
0.001 (25 C)
Vapor density (air=1)
5.8
Density
1.160 g/cm3 (20 C)
Solubility in water
2 g/L (20 C)
pKa/pKb
9.72 (pKb)
Partition coefficient, pKow
2.80
Heat of fusion
16.2 kJ/mol
Heat of vaporization
54.2 kJ/mol
Heat of combustion
-6381 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Oxidized by air.
Incompatibilities
Incompatible with acids and acid anhydrides May react with strong oxidizing agents.
Decomposition
When strongly heated, emits toxic fumes.

Fire.
Flash Point,°C
147
Autoignition, °C
450
Upper exp. limit, %
5.5
Lower exp. limit, %
0.7
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.
Fire potential
This chemical is probably combustible.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
TLV: ppm; mg/m3 A1 (skin) (ACGIH 1996). MAK: class III A1 (1995). OSHA PEL: 1910.1011 See Appendix B NIOSH REL: Ca See Appendix A NIOSH IDLH: Potential occupational carcinogen
Carcinogin
O, G-A1, I-1, N-1, CP65
Poison_Class
1*
Exposure effects
Headache, dizziness, lethargy, and ataxia may occur. 4-Aminodiphenyl crosses the placenta in humans and rats. It is present in breast milk of rats, and DNA adducts can be detected in livers of rats nursing from treated dams.
   Ingestion
See Inhalation.
   Inhalation
Exposure may produced dyspnea.
   Skin
4-aminodiphenyl is an irritant.
   Eyes
4-Aminodiphenyl is an eye irritant.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
3259
Response guide
Hazard class
8
Packing Group
I; II; III
 
USCG CHRIS Code
ABP