4-Aminophenol

  • p-Aminophenol
  • p-Hydroxyaniline
  • 4-Amino-1-hydroxybenzene
Formula
4-(NH2)C6H4OH
Structure
Description
White or reddish-yellow crystals or light brown powder. Turns violet when exposed to light.
Uses
Dyeing textiles, hair, furs, feathers, photographic developer, pharmaceuticals, antioxidants, oil additives.

Registry Numbers and Inventories.
CAS
123-30-8
EC (EINECS/ELINCS)
204-616-2
EC Index Number
612-128-00-X
EC Class
Mutagenic Category 3; Harmful; Dangerous for the Environment
R 20/22 50/53 68
S 28 36/37 60 61
RTECS
SJ5075000
RTECS class
Mutagen; Reproductive Effector; Primary Irritant
UN (DOT)
2512
Merck
13,461
Beilstein/Gmelin
385836
Beilstein Reference
4-13-00-01014
Swiss Giftliste 1
G-1091
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H7NO
Formula mass
109.13
Melting point, °C
186
Boiling point, °C
284
Vapor pressure, mmHg
0.002 (25 C)
Density
1.3 g/cm3
Solubility in water
15 g/L
Refractive index
1.5764 (20 C)
pKa/pKb
8.72 (pKb)
Partition coefficient, pKow
0.04
Heat of vaporization
54.2 kJ/mol
Heat of combustion
-3171 kJ/mol

Hazards and Protection.
Storage
Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Wash hands before eating. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions.
Stability
Stable under normal temperatures and pressures. May discolor on exposure to light.
Incompatibilities
Acids, chloroformates, strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
124
Autoignition, °C
> 250
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
Combustible material: may burn but does not ignite readily.
Hazards
Containers may explode when heated.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Poison_Class
3
Exposure effects
Acute poisoning may cause rapid heart rate and rapid breathing. Severe headache, CNS disturbances, and tremor may occur. A high incidence of gynecological disorders and excess frequency of spontaneous abortions have been noted. The fetal liver can n-oxygenate aniline to form phenylhydroxylamine. Fetal effects include higher levels of methemoglobin those found in than the mother. Fetal poisoning may occur. <br>No data were available to assess the potential effects of exposure to aniline during lactation. <br>No information about possible male reproductive effects was found in available references at the time of this review
   Ingestion
Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause methemoglobinemia, cyanosis, convulsions, and death.
   Inhalation
Causes respiratory tract irritation. May cause methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea, and death. May cause asthmatic attacks due to allergic sensitization of the respiratory tract.
   Skin
Causes skin irritation. Prolonged and/or repeated contact may cause irritation and/or dermatitis. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2512
Response guide
Hazard class
6.1
Packing Group
III
 
HS Code
2922 29 00