4-Chloroaniline

  • p-Chloroaniline
  • p-Chloroaminobenzene
  • 4-Chloroaniline
Formula
ClC6H4NH2
Structure
Description
White to pale yellow to tan colored, crystalline solid, slightly sweetish, characteristic amine odor.
Uses
Dye int, pharmaceuticals, agricultural chemicals.

Registry Numbers and Inventories.
CAS
106-47-8
EC (EINECS/ELINCS)
203-401-0
EC Index Number
612-137-00-9
EC Class
Carcinogenic Category 2; Toxic; Sensitising; Dangerous for the Environment
R 45 23/24/25 43 50/53
S 53 45 60 61
RTECS
BX0700000
RTECS class
Tumorigen; Mutagen; Primary Irritant
UN (DOT)
2018
Merck
13,2136
Beilstein/Gmelin
471350
Beilstein Reference
4-12-00-01166
RCRA
P024
EPA OPP
17203
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H6ClN
Formula mass
127.57
Melting point, °C
69 - 71
Boiling point, °C
232
Vapor pressure, mmHg
0.061 (25 C)
Vapor density (air=1)
4.41
Saturation Concentration
20 ppm (0.002%) at 20 C (calculated)
Critical temperature
460
Critical pressure
46.4
Density
1.43 g/cm3 (20 C)
Solubility in water
Slightly soluble
Viscosity
1.964 cp (55 C)
Surface tension
37.8 g/s2 (75 C)
Refractive index
1.5546 (87 C)
pKa/pKb
10.03 (pKb)
Partition coefficient, pKow
1.83
Heat of vaporization
79.0 kJ/mol
Heat of combustion
-7669 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use.
Handling
Wash thoroughly after handling. Wash hands before eating. Use only in a well ventilated area. Minimize dust generation and accumulation. Do not get on skin or in eyes. Do not ingest or inhale. Wash clothing before reuse.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Reduce airborne dust and prevent scattering by moistening with water. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions.
Disposal code
9
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Acids, acid chlorides, acid anhydrides, chloroformates, and strong oxidizing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
90
Autoignition, °C
> 500
Upper exp. limit, %
8.8
Lower exp. limit, %
2.2
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
Very flammable.
Hazards
Containers may explode when heated.
Combustion products
Irritating and toxic hydrogen chloride and oxides of nitrogen may form in fires.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Carcinogin
I-2B, CP65
Exposure effects
May cause liver and kidney damage. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death. May cause cancer according to animal studies. May cause reproductive and fetal effects.
   Ingestion
Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. Overexposure may cause methemoglobinemia.
   Inhalation
May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown blood. Inhalation of aniline causes anoxia due to the formation of methemoglobinemia.
   Skin
Causes skin irritation. Harmful if absorbed through the skin. Prolonged and/or repeated contact may cause irritation and/or dermatitis.
   Eyes
Causes severe eye irritation.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2018
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
CAP
 
HS Code
2921 42 10
 
Std. Transport #
4963347