4-Chloromandelic acid

  • p-Chloromandelic acid
  • 4-Chloro-DL-mandelic acid
  • (p-Chlorophenyl)hydroxyacetic acid
  • 2-Hydroxy-2-(4-chlorophenyl)acetic acid
  • Benzeneacetic acid, 4-chloro-a-hydroxy-
Formula
C8H7ClO3
Structure
Description
White solid.

Registry Numbers and Inventories.
CAS
492-86-4
EC (EINECS/ELINCS)
207-764-6
R 36/37/38
Beilstein/Gmelin
1567759
Beilstein Reference
4-10-00-00580
Canada DSL/NDSL
NDSL
US TSCA
Listed

Properties.
Formula
C8H7ClO3
Formula mass
186.59
Melting point, °C
103 - 105
Boiling point, °C
361
Vapor pressure, mmHg
7E-6 (25 C)
Solubility in water
Very soluble
pKa/pKb
3.14 (pKa)
Partition coefficient, pKow
1.52
Heat of fusion
27.21 kJ/mol
Heat of vaporization
64.1 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Wash thoroughly after handling. Wash hands before eating. Use with adequate ventilation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidants.
Decomposition
Hydrogen chloride, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
172
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Health.
Exposure effects
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.