4-Hydroxyisophthalic acid

  • 4-Hydroxy-m-phthalic acid
  • 4-Hydroxy-1,3-benzenedicarboxylic acid
  • 4-HIPA
  • Eupirina
Formula
C8H6O5
Structure
Description
White solid.

Registry Numbers and Inventories.
CAS
636-46-4
EC (EINECS/ELINCS)
211-258-0
RTECS
NT2544000
RTECS class
Drug
Merck
12,4873
Beilstein/Gmelin
2211981
Beilstein Reference
4-10-00-02091
Swiss Giftliste 1
G-3231
Japan ENCS (MITI)
Listed

Properties.
Formula
C8H6O5
Formula mass
182.13
Melting point, °C
316
Vapor density (air=1)
6.3
Solubility in water
Very soluble
pKa/pKb
2.64 (pKa)
Partition coefficient, pKow
0.76

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents - strong bases.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
314
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Poison_Class
4
Exposure effects
   Ingestion
The toxicological properties of this substance have not been fully investigated. Causes gastrointestinal tract irritation.
   Inhalation
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
Causes skin irritation. The toxicological properties of this material have not been fully investigated.
   Eyes
Causes eye irritation. The toxicological properties of this material have not been fully investigated.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.