4-Methoxyphenol

  • p-Methoxyphenol
  • Hydroxyquinone, monomethyl ether
  • p-Hydroxyanisole
  • Mequinol
Formula
C7H8O2
Structure
Description
White to off-white waxy solid or flaky, crystalline material. Odor of caramel and phenol.
Uses
Manufacture of antioxidants, pharmaceuticals, plasticizers, dyestuffs, uv inhibitor, stabilizer for chlorinated hydrocarbons & ethyl cellulose, inhibitor for acrylic monomers & acrylonitriles.

Registry Numbers and Inventories.
CAS
150-76-5
EC (EINECS/ELINCS)
205-769-8
EC Index Number
604-044-00-7
EC Class
Harmful; Irritant; Sensitising
R 22 36 43
S 24/25 26 37/39 46
RTECS
SL7700000
RTECS class
Mutagen; Primary Irritant
UN (DOT)
3335
Beilstein/Gmelin
507924
Beilstein Reference
4-06-00-05717
Swiss Giftliste 1
G-4246
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H8O2
Formula mass
124.14
Melting point, °C
55 - 57
Boiling point, °C
243
Vapor pressure, mmHg
0.02 (25 C)
Vapor density (air=1)
4.2
Saturation Concentration
<13 ppm at 25 C (calculated)
Density
1.55 g/cm3 (20 C)
Solubility in water
40 g/L
Viscosity
4.58 cp (72 C)
Surface tension
29.9 g/s2 (184 C)
pKa/pKb
10.40 (pKa)
Partition coefficient, pKow
1.58
Heat of fusion
18.30 kJ/mol
Heat of vaporization
49.9 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
D2B
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal.
Disposal code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Acid anhydrides, acid chlorides, bases, oxidizing agents.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
121
Autoignition, °C
445
Upper exp. limit, %
9.6
Lower exp. limit, %
1.3
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water fog, dry chemical, carbon dioxide, or regular foam.
Fire potential
Combustible.
Hazards
Combustible
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
NIOSH REL: TWA 5 mg/m3
Poison_Class
4
Exposure effects
Chronic exposure may cause visual disturbances. Prolonged contact may cause severe eye irritation or burns.
   Ingestion
May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns. May be harmful if swallowed.
   Inhalation
May cause respiratory tract irritation.
   Skin
Causes skin irritation. May cause depigmentation of the skin.
   Eyes
Causes eye irritation. May cause eye burns.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
3335
Response guide
21. Phenols. Cresols
HS Code
2909 50 90