4-Methylpyridine

  • 4-Picoline
  • p-Picoline
Formula
4-(CH3)C5H4N
Structure
Description
Colorless moderately volatile liquid.
Uses
Manufacture of isonicotinic acid and derivatives, in water-proofing agents for fabrics, as solvent for resins.

Registry Numbers and Inventories.
CAS
108-89-4
EC (EINECS/ELINCS)
203-626-4
EC Index Number
613-037-00-8
EC Class
Flammable; Toxic; Harmful; Irritant
R 10 20/22 24 36/37/38
S 26 36 45
RTECS
UT5425000
RTECS class
Primary Irritant
UN (DOT)
2313
Merck
12,7556
Beilstein/Gmelin
104586
Beilstein Reference
5-20-05-00543
Swiss Giftliste 1
G-3179
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H7N
Formula mass
93.13
Melting point, °C
3
Boiling point, °C
144.9
Vapor pressure, mmHg
6.5 (25 C)
Vapor density (air=1)
3.2
Critical temperature
374
Critical pressure
46.0
Density
0.9547 g/cm3 (20 C)
Solubility in water
Soluble
Viscosity
0.94 cp (20 C)
Refractive index
1.5064 (20 C)
pKa/pKb
6.04 (pKb)
Partition coefficient, pKow
1.22
Heat of vaporization
44.9 kJ/mol
Heat of combustion
-3421 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Store protected from moisture.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Remove all sources of ignition. Use a spark-proof tool. Do not get water inside containers. A vapor suppressing foam may be used to reduce vapors.
Disposal code
9
Stability
Stable under normal temperatures and pressures. Hygroscopic: absorbs moisture or water from the air.
Incompatibilities
Moisture, water, oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
50
Autoignition, °C
> 500
Upper exp. limit, %
8.7
Lower exp. limit, %
1.3
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Extinguishing media: Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT get water inside containers. Do NOT use straight streams of water. For large fires, use water spray, fog or regular foam. For small fires, use dry chemical, carbon dioxide, water spray or regular foam.
Fire potential
Moderate fire risk
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.
Combustion products
Fire will produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
PDK (as mixture of isomers): 5 mg/m3 (USSR 1991).
Poison_Class
4
Exposure effects
May cause liver and kidney damage. Effects may be delayed.
   Ingestion
May cause irritation of the digestive tract. Ingestion of large amounts may cause CNS depression. Intoxication may include weight loss, diarrhea, weakness, ataxia, and unconsciousness.
   Inhalation
Causes irritation of mucous membrane. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. Exposure may give rise to flushing of face, skin rash, an increase in heart and respiration rates, headaches, giddiness, nausea, and vomiting. May cause burning sensation in the chest.
   Skin
Causes skin irritation. Harmful if absorbed through the skin. May cause reddening of the skin. May cause skin rash and eruptions. Substance is readily absorbed through the slkin. May cause cyanosis of the extremities.
   Eyes
Causes eye irritation. May cause chemical conjunctivitis and corneal damage.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2313
Response guide
Hazard class
3
Packing Group
III
 
USCG CHRIS Code
MPF
 
9 Aromatic amines
HS Code
2933 39 55
 
IMO Chemical Code
17
IMO Pollution Category
D
IMO Hazard code
S