4-Nitroaniline

  • p-Aminonitrobenzene
  • p-Nitroaniline
  • 1-Amino-4-nitrobenzene
Formula
H2NC6H4NO2
Structure
Description
Yellow solid, ammonia-like odor.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
100-01-6
EC (EINECS/ELINCS)
202-810-1
EC Index Number
612-012-00-9
EC Class
Toxic; Danger of cumulative effects; Dangerous for the Environment
R 23/24/25 33 52/53
S 28 36/37 45 61
RTECS
BY7000000
RTECS class
Tumorigen; Mutagen; Reproductive Effector
UN (DOT)
1661
Merck
12,6681
Beilstein/Gmelin
508690
Beilstein Reference
4-12-00-01613
RCRA
P077
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H6N2O2
Formula mass
138.12
Melting point, °C
148
Boiling point, °C
332
Vapor pressure, mmHg
0.0001 (25 C)
Vapor density (air=1)
4.77
Saturation Concentration
1.97 ppm (0.0001 %) at 20 C (calculated)
Density
1.24 g/cm3
Solubility in water
0.8 g/L
Viscosity
0.144 cp (172 C)
Surface tension
46.7 g/s2 (151 C)
Refractive index
1.5401 (160 C)
pKa/pKb
12.99 (pKb)
Partition coefficient, pKow
1.39
Heat of fusion
21.1 kJ/mol
Heat of vaporization
57.6 kJ/mol
Heat of combustion
-3173 kJ/mol

Hazards and Protection.
Storage
Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Keep container tightly closed. Do not get on skin or in eyes. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Wear a self contained breathing apparatus and appropriate Personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Provide ventilation.
Disposal code
9
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Strong acids, strong oxidizing agents, strong redcing agents.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
165
Autoignition, °C
500
Upper exp. limit, %
9.8
Lower exp. limit, %
1.5
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.
Fire potential
Slightly flammable. Will burn in air, producing highly toxic vapors.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Toxic oxides of nitrogen may form in fire.
Health
3
 
Flammability
1
 
 
Reactivity
2
 

Health.
Exposure limit(s)
OSHA PEL: TWA 6 mg/m3 (1 ppm) skin NIOSH REL: TWA 3 mg/m3 skin NIOSH IDLH: 300 mg/m3
Exposure effects
Prolonged or repeated exposure may cause adverse reproductive effects. May cause liver and kidney damage. May cause bone marrow abnormalities with damage to blood forming tissues. May cause anemia and other blood cell abnormalities. Repeated exposure may cause central nervous system damage. Reproductive effects have been reported in animals.
   Ingestion
May cause methemoglobinemia, cyanosis, convulsions, and death. Effects may be delayed 2 to 4 hours. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May be harmful if swallowed. Alcohol can intensify effects.
   Inhalation
May cause respiratory tract irritation. May cause effects similar to those described for ingestion. Inhalation of aniline causes anoxia due to the formation of methemoglobinemia.
   Skin
May cause skin irritation. Substance is rapidly absorbed through the skin. If absorbed, may cause symptoms similar to those for ingestion.
   Eyes
May cause eye irritation. Vapors may cause eye irritation. May cause eye injury.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Induce vomiting by giving one teaspoon of Syrup of Ipecac.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1661
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
NAL
 
HS Code
2921 42 10