4-Nitrophenol

  • 4-Hydroxynitrobenzene
  • p-Nitrophenol
Formula
O2NC6H4OH
Structure
Description
A white to light yellow crystalline solid.
Uses
As indicator in 0.1% Alcohol soln, ph range: 5.6 Colorless, 7.6 Yellow.

Registry Numbers and Inventories.
CAS
100-02-7
EC (EINECS/ELINCS)
202-811-7
EC Index Number
609-015-00-2
EC Class
Harmful; Danger of cumulative effects
R 20/21/22 33
RTECS
SM2275000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Mutagen
UN (DOT)
1663
Merck
12,6718
Beilstein/Gmelin
1281877
Beilstein Reference
4-06-00-01279
RCRA
U170
EPA OPP
56301
Swiss Giftliste 1
G-181560
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H5NO3
Formula mass
139.11
Melting point, °C
110 - 114
Boiling point, °C
279
Vapor pressure, mmHg
0.6 (120 C)
Vapor density (air=1)
1.244
Odor Threshold Odor threshold 58.3 mg/L
Density
1.236 g/cm3 (160 C)
Solubility in water
16 g/L
Viscosity
2.56 cp (21 C)
Surface tension
46.3 g/s2 (121 C)
pKa/pKb
7.15 (pKa)
Partition coefficient, pKow
1.91
Heat of fusion
24.2 kJ/mol
Heat of vaporization
56.2 kJ/mol
Heat of combustion
-2869 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Keep away from food and drinking water. Keep from contact with oxidizing materials.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid prolonged or repeated contact with skin. Wash clothing before reuse.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Disposal code
3
Stability
Stable under normal shipping and handling conditions.
Incompatibilities
Strong oxidizing agents; Strong bases; Diethyl phosphite
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
142
Autoignition, °C
283
Fire fighting
Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources.
Fire potential
Slightly flammable. Combustible solid, may thermally decompose in absence of air.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Toxic oxides of nitrogen and fumes of unburned material may form in fires.
Health
3
 
Flammability
1
 
 
Reactivity
2
 

Health.
Poison_Class
2
Exposure effects
May cause liver and kidney damage.
   Ingestion
Harmful if swallowed. May cause central nervous system depression, kidney damage, and liver damage. May cause methemoglobinemia, cyanosis, convulsions, and death. May cause digestive tract disturbances.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause severe skin irritation.
   Eyes
May cause severe eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Call a poison control center.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1663
Response guide
Hazard class
6.1
Packing Group
III
 
USCG CHRIS Code
NPH
 
HS Code
2908 90 00
 
Std. Transport #
4925211