4-Nitrosophenol

  • 1,4-Benzoquinone monoxime
  • Nitrosophenol
  • para-Nitrosophenol
  • Quinone monoxime
  • Quinone oxime
Formula
C6H5NO2
Structure
Description
Yellow to brown powder.
Uses
Manufacture of dyes.

Registry Numbers and Inventories.
CAS
104-91-6
EC (EINECS/ELINCS)
203-251-6
EC Index Number
604-042-00-6
EC Class
Mutagenic Category 3; Harmful; Irritant; Dangerous for the Environment
RTECS
SM4725000
RTECS class
Mutagen
Merck
12,6740
Beilstein/Gmelin
1856695
Beilstein Reference
4-07-00-02073
Swiss Giftliste 1
G-2658
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H5NO2
Formula mass
123.11
Melting point, °C
130
Boiling point, °C
266
Vapor pressure, mmHg
0.005 (25 C)
Solubility in water
8 g/L
pKa/pKb
6.48 (pKa)
Partition coefficient, pKow
1.43
Heat of vaporization
52.4 kJ/mol
Heat of combustion
-3005 kJ/mol

Hazards and Protection.
Storage
Keep away from sources of ignition. Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container. Flammables-area.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear protective safety goggles or face shield as described in 29 CRF 1910.133 or European Standard EN166. Skin contact should be eliminated by wearing the appropriate chemical protective gloves annd clothing.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid generating dusty conditions. Remove all sources of ignition. Use a spark-proof tool.
Stability
No data.
Incompatibilities
Strong acids, bases.
Decomposition
Carbon monoxide, oxides of nitrogen, carbon dioxide.

Fire.
Flash Point,°C
115
Autoignition, °C
390
Fire fighting
Wear a self-contained breathing apparatus inpressure-demand, MSHA/NIOSH (approved or equivalent), and fullprotective gear. This material poses an explosion hazard when dry.Flammable solid. In case of fire use water spray, dry chemical, carbon dioxide, orchemical foam.

Health.
Poison_Class
1
Exposure effects
Abnormally low blood pressure, reduced body temperature, rapid breathing, and rapid heart rate may develop with severe toxicity. Initial CNS excitation, including seizures, is commonly followed by CNS depression ranging from lethargy to coma and death. Fetotoxicity and skeletal abnormalities have been reported in animal experiments.
   Ingestion
Phenol is extremely corrosive and may cause oral and esophageal burns and abdominal pain following ingestion.
   Inhalation
Tachypnea is commonly reported; pulmonary edema and bronchospasm may also occur. Stridor has been reported from exposure to high concentrations of phenol. Respiratory arrest occurred 30 minutes post ingestion of 26.7 Grams of phenol in one case.
   Skin
Phenol is corrosive to the skin, but because of anesthetic qualities, it will numb rather than causing a burning pain on contact. Skin becomes red and swollen, then white and opaque. Deep burns result that may become gangrenous.
   Eyes
May cause eye irritation and possible damage.

First aid
 
   Ingestion
Dilution - may enhance absorption of phenol, and should be avoided. Emesis: ipecac-induced vomiting is not recommended because of the potential for cns depression and seizures. Activated charcoal - may limit systemic toxicity if administered soon after ingestion, but may interfere with endoscopic evaluation of gastrointestinal burns.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.