4-Pyridinecarbonitrile

  • 4-Cyanopyridine
Formula
4-(CN)C5H4N
Structure
Description
White to light yellow crystalline solid.

Registry Numbers and Inventories.
CAS
100-48-1
EC (EINECS/ELINCS)
202-856-2
EC Class
irritant
R 22 36/37/38
S 26 36/37/39
UN (DOT)
2811
Beilstein/Gmelin
107712
Beilstein Reference
5-22-02-00214
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H4N2
Formula mass
104.11
Melting point, °C
78 - 80
Boiling point, °C
195.4
Vapor pressure, mmHg
0.4 (25 C)
Solubility in water
32 g/L
pKa/pKb
12.08 (pKb)
Partition coefficient, pKow
0.41
Heat of vaporization
43.3 kJ/mol
Heat of combustion
-3143 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.
Disposal code
6
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents - strong acids - strong bases.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
83
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. Do NOT get water inside containers. Cool containers with flooding quantities of water until well after fire is out. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
   Ingestion
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled.
   Skin
May cause skin irritation. Harmful if absorbed through the skin.
   Eyes
May cause severe eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
HS Code
2933 39 99