4-Trifluoromethoxybenzyl bromide

  • 4-(Trifluoromethoxy)benzyl bromide
  • 1-Bromomethyl-4-trifluoromethoxybenzene
  • Benzene, 1-(bromomethyl)-4-(trifluoromethoxy)-
Formula
C8H6BrF3O
Structure
Description
Clear faint yellow liquid.

Registry Numbers and Inventories.
CAS
50824-05-0
R 34 36
S 26 36/37/39 45
UN (DOT)
3265
Beilstein/Gmelin
2521451

Properties.
Formula
C8H6BrF3O
Formula mass
255.03
Melting point, °C
23 - 24
Boiling point, °C
203
Vapor pressure, mmHg
0.40 (25 C)
Vapor density (air=1)
8.79
Density
1.58 g/cm3
Solubility in water
Insoluble
Refractive index
1.48 (20 C)
Partition coefficient, pKow
3.87
Heat of vaporization
42.2 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area. Keep containers tightly closed. Store protected from moisture.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Do not allow contact with water. Use only in a chemical fume hood. Discard contaminated shoes. Keep from contact with moist air and steam.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Cover with sand, dry lime or soda ash and place in a closed container for disposal. Provide ventilation. Do not get water inside containers.
Stability
Stable under normal temperatures and pressures. Moisture sensitive.
Incompatibilities
Strong oxidizing agents, strong bases, moisture.
Decomposition
Carbon monoxide, carbon dioxide, hydrogen fluoride, hydrogen bromide.

Fire.
Flash Point,°C
94
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Do NOT get water inside containers.
Health
3
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
Effects may be delayed.
   Ingestion
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May cause systemic effects.
   Inhalation
Causes chemical burns to the respiratory tract. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. May cause systemic effects. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
   Skin
Causes skin burns. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
   Eyes
Causes eye burns. Lachrymator. May cause chemical conjunctivitis and corneal damage.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Transport.
UN number
3265
Response guide