4-(Trifluoromethyl)aniline

  • p-Aminobenzotrifluoride
  • 4-Aminobenzotrifluoride
  • 4-(Trifluoromethyl)benzenamine
  • (4-(Trifluoromethyl)phenyl)amine
Formula
4-(NH2)C6H4CF3
Structure
Description
Clear yellow liquid.

Registry Numbers and Inventories.
CAS
455-14-1
EC (EINECS/ELINCS)
207-236-5
EC Class
irritant
R 23/24/25 33 36/38
S 26 36/37/39 45
RTECS
XU9260000
RTECS class
Drug; Mutagen
UN (DOT)
3276
Beilstein/Gmelin
1564853
Beilstein Reference
4-12-00-01982
Canada DSL/NDSL
NDSL
US TSCA
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H6F3N
Formula mass
161.13
Melting point, °C
3 - 8
Boiling point, °C
190
Vapor pressure, mmHg
0.55 (25 C)
Vapor density (air=1)
5.6
Density
1.2901 g/cm3 (25 C)
Solubility in water
Insoluble
Refractive index
1.4851 (20 C)
pKa/pKb
11.23 (pKb)
Partition coefficient, pKow
1.95
Heat of vaporization
42.6 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Wash clothing before reuse. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation.
Disposal code
2
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Oxidizing agents
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen fluoride, nitrogen.

Fire.
Flash Point,°C
86
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Extinguishing media: Use water spray to cool fire-exposed containers. Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
Non-Combustible
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
1
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure effects
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
Causes skin irritation. The toxicological properties of this material have not been fully investigated.
   Eyes
Causes eye irritation. The toxicological properties of this material have not been fully investigated.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
3276
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
HS Code
2921 43 00