- N,N'-(1,1'-biphenyl)-4,4'-diylbis-acetamide 4',4'''-biacetanilide
Needles from acetic acid.
Used to prepare 3,3'-dichlorobenzidine and 3,3'-dinitrobenzidine.
Registry Numbers and Inventories.
EC Index Number
Boiling point, °C
Vapor pressure, mmHg
0.15 (25 C)
0.9272 g/cm3 (25 C)
Solubility in water
Heat of vaporization
Heat of combustion
Hazards and Protection.
Storage should be close to laboratory where material is to be used, so that only small amounts need to be carried. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should be appropriately labeled. An inventory should be kept showing the quantity of carcinogen and date it was acquired. Facilities for dispensing should be contiguous to storage area.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Dispensers of liquid detergent should be available. In the laboratory, gloves and protective clothing should always be worn but should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, and disposable plastic aprons might provide additional protection. Protective clothing should be of distinctive color, as a reminder not to be worn outside the laboratory.
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Change on exposure to light, due to photooxidation.
Strong oxidizing agents.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
CNS effects include headache, dizziness, altered mental status, confusion (lethargy progressing coma), seizures, syncope; occur secondary to CNS hypoxia, usually with levels > 20%.
Nausea and vomiting may occur.
Dyspnea and tachypnea may occur.
Central cyanosis unresponsive to oxygen therapy is classic.
Emesis: ipecac-induced vomiting is not recommended because of the potential for cns depression and seizures. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents. Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Oxygen - administer oxygen to all cyanotic or symptomatic patients. Methemoglobinemia: administer 1 to 2 mg/kg of 1% methylene blue slowly iv in symptomatic patients. Additional doses may be required. Shock and cardiac arrest - treat routinely. Adjunctive therapy - exchange transfusions and hyperbaric oxygen may be useful in severe cases.
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Some methemoglobinemia producing chemicals are readily absorbed through the skin to produce adverse systemic effects. Aniline and related compounds may be rapidly absorbed by all routes. Skin contact with contaminated clothing or shoes may result in adverse systemic effects. Skin should be thoroughly washed with soap and water. Contaminated clothing and shoes should be discarded. Seek medical attention. Administer 100 percent humidified supplemental oxygen with assisted ventilation as required. Treat for methemoglobinemia and sequelae. Signs and symptoms of methemoglobinemia may be delayed. Methemoglobinemia: administer 1 to 2 mg/kg of 1% methylene blue slowly iv in symptomatic patients. Additional doses may be required.
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.