5-Aminouracil

  • 5-Amino-2,4-dihydroxypyrimidine
  • -Amino-2,4-pyrimidinediol
  • 5-Amino-2,4(1H,3H)-pyrimidinedione
  • 2,4-Dihydroxy-5-aminopyrimidine
  • 2,4(1H,3H)-Pyrimidinedione, 5-amino-
Formula
C4H5N3O2
Structure
Description
Tan powder.

Registry Numbers and Inventories.
CAS
932-52-5
EC (EINECS/ELINCS)
213-252-3
S 22 24/25
RTECS
YQ8740000
RTECS class
Mutagen
Beilstein/Gmelin
127250
Beilstein Reference
5-25-15-00428
Canada DSL/NDSL
NDSL
US TSCA
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C4H5N3O2
Formula mass
127.10
Melting point, °C
300
Boiling point, °C
377
Solubility in water
Very soluble
pKa/pKb
4.80 (pKb)
Partition coefficient, pKow
-2.49

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store under an inert atmosphere.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Avoid ingestion and inhalation. Handle under an inert atmosphere. Store protected from air.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation. Place under an inert atmosphere.
Stability
Stable under normal shipping and handling conditions.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Laboratory experiments have resulted in mutagenic effects.
   Ingestion
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.