5-Bromouracil

  • 5-Bromo-2,4-pyrimidinedione
  • 5-Bromo-2,4-dihydroxypyrimidine
  • 2,4(1H,3H)-Pyrimidinedione, 5-bromo-
Formula
C4H3BrN2O2
Structure
Description
White powder.
Uses
Exptly as mutagen.

Registry Numbers and Inventories.
CAS
51-20-7
EC (EINECS/ELINCS)
200-084-0
RTECS
YQ9060000
RTECS class
Mutagen; Reproductive Effector
UN (DOT)
2811
Merck
13,1425
Beilstein/Gmelin
127176
Beilstein Reference
5-24-06-00322
Canada DSL/NDSL
NDSL
US TSCA
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C4H3BrN2O2
Formula mass
190.99
Melting point, °C
165
Boiling point, °C
384
Solubility in water
Very soluble
pKa/pKb
5.87 (pKb)
Partition coefficient, pKow
-0.64

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen bromide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use water spray, dry chemical, or carbon dioxide.

Health.
Exposure effects
May cause cancer in humans.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Induce vomiting by giving one teaspoon of Syrup of Ipecac.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2811
Response guide
HS Code
2933 59 95