5-Chloro-2-nitroaniline

  • 2-Amino-4-chloro-1-nitrobenzene
  • Benzenamine, 5-chloro-2-nitro-
  • 2-Amino-4-chloronitrobenzene
  • 2-Nitro-5-chloroaniline
  • 5-Chloro-2-nitrobenzenamine
  • 5-Chloro-2-nitrophenylamine
Formula
2-(NO2)-5-(Cl)C6H3NH2
Structure
Description
Yellow to orange powder

Registry Numbers and Inventories.
CAS
1635-61-6
EC (EINECS/ELINCS)
216-661-5
EC Index Number
610-006-00-0
EC Class
very toxic, dangerous for the environment
R 26/27/28 33 51/53
S 28.1 36/37 45 61
UN (DOT)
2237
Beilstein/Gmelin
2210201
Beilstein Reference
4-12-00-01673
Canada DSL/NDSL
DSL
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C6H5ClN2O2
Formula mass
172.57
Melting point, °C
123 - 126
Boiling point, °C
323
Vapor pressure, mmHg
0.0003 (25 C)
Solubility in water
1.2 g/L
Partition coefficient, pKow
2.76
Heat of vaporization
56.5 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Minimize dust generation and accumulation. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use only in a chemical fume hood.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Disposal code
9
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Strong bases, oxidizing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
149
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Containers may explode when heated. Runoff from fire control or dilution water may cause pollution. Extinguishing media: For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
Combustible material: may burn but does not ignite readily.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death. Effects may be delayed. May cause cyanosis - a blue-gray coloring of the skin and lips caused by a lack of oxygen.
   Ingestion
May cause irritation of the digestive tract. May cause liver and kidney damage. May cause cardiac disturbances. May cause methemoglobinemia, cyanosis, convulsions, and death. May cause central nervous system depression.
   Inhalation
May cause respiratory tract irritation. May cause methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea, and death. May cause liver and kidney damage. May cause cardiac abnormalities. Inhalation at high concentrations may cause CNS depression and asphixiation.
   Skin
May cause skin irritation. Absorption into the body may cause cyanosis.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2237
Response guide
Hazard class
6.1
Packing Group
III
 
HS Code
2921 42 10