5-Fluorouracil

  • 5-Fluoro-2,4(1H,3H)-pyrimidinedione
Formula
C4H3FN2O2
Structure
Description
White to nearly white crystalline powder; practically odorless.
Uses
medication.

Registry Numbers and Inventories.
CAS
51-21-8
EC (EINECS/ELINCS)
200-085-6
EC Class
harmful
R 46 60 61 23/24/25
RTECS
YR0350000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
UN (DOT)
2811
Merck
13,4208
Beilstein/Gmelin
127172
Beilstein Reference
5-34-06-00271
Swiss Giftliste 1
G-3825
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C4H3FN2O2
Formula mass
130.08
Melting point, °C
282 - 283
Boiling point, °C
347
Critical temperature
591
Critical pressure
55.3
Solubility in water
Very soluble
pKa/pKb
7.88 (pKa)
Partition coefficient, pKow
-0.78
Heat of fusion
28.62 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Store protected from light. Use only in a chemical fume hood.
Protection
Eyes: Wear chemical goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear a chemical apron.
Respirators
A NIOSH/MSHA approved air purifying dust or mist respirator or European Standard EN 149.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Disposal code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride.

Fire.
Flash Point,°C
280
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use water spray, dry chemical, or carbon dioxide.
Hazards
Emits very toxic fumes of flourides and nitrogen oxides when heated to decomposition. Avoid decomposing heat.

Health.
Poison_Class
1*
Exposure effects
Prolonged or repeated exposure may cause adverse reproductive effects.
   Ingestion
Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
Harmful if inhaled. Causes respiratory tract irritation.
   Skin
Causes skin irritation. Harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2811
Response guide
USCG CHRIS Code
FRA
 
HS Code
2933 59 95