5-beta-Bufa-20,22-dienolide, 3-beta,14-dihydroxy

  • Bufa-20,22-dienolide, 3,14-dihydroxy-, (3-beta,5-beta)-
  • Bufalin
  • 3-beta,14-Dihydroxy-5-beta-bufa-20,22-dienolide
Formula
C24H34O4
Description
White solid.
Uses
A cardiotonic steroid isolated from Bufo species toads that potently inhibits ouabain-sensitive Na+,K+-ATPase activity. Induces apoptosis in various human cell lines such as leukemia HL60 and U937 cells by altering the expression of apoptosis-related genes.

Registry Numbers and Inventories.
CAS
465-21-4
RTECS
EI2962500
Merck
12,1493
Beilstein/Gmelin
5141601

Properties.
Formula
C24H34O4
Formula mass
386.53
Melting point, °C
242 - 243
Vapor pressure, mmHg
1.1E-14 (25 C)
Density
1.226 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
14.74
Partition coefficient, pKow
3.42

Hazards and Protection.
Storage
Store at -20 C, protect from light.
Stability
Stable for a year if stored as directed.
Incompatibilities
Air sensitive.

Fire.

Health.
Exposure effects

First aid
 

Transport.