5a-Pregnane-3a,11b,17a,21-tetrol-20-one

  • 3a,11b,17a,21-Tetrahydroxy-5a-pregnan-20-one
  • 3a,5a-Tetrahydrocortisol
  • Allopregnane-3a,11b,17a,21-tetrol-20-one
  • Allotetrahydrocortisol
  • Reichstein’s substance C
  • Kendall’s compound C
Formula
C21H34O5
Structure

Registry Numbers and Inventories.
CAS
302-91-0
EC (EINECS/ELINCS)
206-131-1
Merck
13,270

Properties.
Formula
C21H34O5
Formula mass
366.5
Melting point, °C
244 - 245
Boiling point, °C
545
Vapor pressure, mmHg
3.7E-14 (24 C)
Density
1.25 g/L (20 C)
Solubility in water
59 mg/L (25 C)
pKa/pKb
12.49 (pKa)
Partition coefficient, pKow
2.23
Heat of vaporization
94.73 kJ/mol

Hazards and Protection.
Storage
Keep container tightly closed.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles. Protective clothing.
Respirators
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Respiratory protection is not required. Where protection is desired, use multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Oxides of carbon.

Fire.
Flash Point,°C
297
Fire fighting
Extinguish with water spray, carbon dioxide, dry chemical powder or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
3
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
May be harmful by inhalation, ingestion, or skin absorption. Some steroids show carcinogenic and teratogenic activity.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.